Relation of serum visfatin level and uterine artery Doppler to preeclampsia

Authors

  • Mohamed Abd El-Moety El-Samra Department of Obstetrics and Gynecology, Alexandria Faculty of Medicine, Egypt
  • Sherif Mansour Aggag Department of Clinical Pathology, Egyptian Ministry of Health, Alexandria, Egypt

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20175831

Keywords:

Adipocytokines, Mild preeclampsia, Pregnancy, Severe preeclampsia, Uterine artery Doppler ultrasound, Visfatin

Abstract

Background: Preeclampsia (PE) is a significant cause of remarkable fetomaternal morbidity and mortality worldwide. Visfatin is 52 KDa novel adipokine, pre B cell colony enhancing factor (PBEF) which could be used as a biochemical marker predictor or a diagnostic tool for preeclampsia. Trans abdominal pulsed Doppler ultrasound (US) monitor the impedance to blood flow in the uterine arteries in pregnant females and those with preeclampsia. Visfatin has been implicated in the pathogenesis of preeclampsia with a limited contradictory. The aim of our study is to monitor the risky pregnant females through Visfatin level and transabdominal pulsed Doppler of the uterine artery.

Methods: Assessment of the serum Visfatin levels in the maternal circulation of preeclamptic pregnant females wether mild or severe, and compared to those in the normal pregnant subjects as control through recruitment of cases of mild PE (n=40), severe PE (n=40), normal pregnant subjects (n=60) in a cross sectional study where the cases were of the patients hospitalized at El Shatby Hospital of Obstetrics and Gynecology, and the control subjects were of referrals to the outpatient departments. Fasting blood samples were drawn, kept at -20 degree centigrades , enzyme linked immune sorbant assay (ELISA) Test was performed on them to determine the Visfatin level and recorded the uterine arteries pulsatility index through transabdominal doppler ultrasound. Lastly, the data were analysed using (F test) ANOVA statistical method.

Results: Amongst the groups, Serum visfatin level was significantly higher in the severe preeclamptic group rather than the normal pregnant group and those with mild preeclampsia (p<0.001). Uterine artery pulsatility index was significantly higher in the severe preeclamptic group rather than the normal pregnant group and those with mild preeclampsia (p<0.001).

Conclusions: Severe preeclamptic pregnant females were shown to represent higher circulating visfatin levels as one of the most recent biochemical markers of preeclampsia, higher uterine artery pulsatility index compared to normal pregnant and those with mild preeclamptic groups of women.

References

Redman CW, Sargent IL: Latest advances in understanding preeclampsia. Science. 2005;308:1592-4.

Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365:785-99.

Taylor RN. Immunology of preeclampsia. Am J Reo Immuonol. 1997;37:79-88.

Fasshauer M, Waldeyer T, Seeger J, Schrey S, Ebert T et al. Serum levels of the adipokine visfatin are increased in preeclampsia. Clin Endocrinol. 2008;69(1):69-73.

Wensheng Hu, Zhengping W, Hanzhi W, Hefeng H, Minyue D. Serum visfatin levels in late pregnancy and preeclampsia. Acta Obstet Gynecol. 2008;87:413-8.

Poston L. Leptin and preeclampsia. Semin Report Med. 2002;20:131-8.

Ma Y, Cheng Y, Wang J, Cheng H, Zhou S, Li X. The changes of visfatin in serum and its expression in fat and placental tissue in pregnant women with gestational diabetes. Diabetes Res Clin Pract. 2010;90:60-5.

Jia SH, LI Y, Parodo J, Kampus A, Fan L, Rotstein OD, et al. Pre-B cell colony enhancing factor inhibit neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest. 2004;113:1318-27.

Marvin KW, Keelan JA, Eykholt RL, Sato TA, Mitchell MD. Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm. Mol Hum Reprod. 2002;8:399-408.

Ognjanovic S, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes. Am J Obstet Gynecol. 2002;187:1051-8.

Brosens I, Pijnenborg R, Vercruysse L, Romero R. The Great Obstetrical Syndromes are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204:193-201.

Yu CKH, Smith GCS, Papageorghiou AT, Cacho AM, Nicolaides KH. An integrated model for the prediction of preeclampsia using maternal factors and uterine artery Doppler velocimetry in unselected low risk women. Am J Obstet Gynecol. 2005;193:429-436.

Plasencia W, Maiz N, Bonino S, Kaihura C, Nicolaides KH. Uterine artery Doppler at 11‏0 to 13‏6 weeks in the prediction of preeclampsia. Ultrasound Obstet Gynecol. 2007;30:742-9.

Lorentzen B, Birkeland KI, Endresen MJ, Henriksen T. Glucose intolerance in women with preeclampsia. Acta Obstet Gynecol Scand. 1998;77:22-7.

Vatten LJ, Skjaerven R. Is pre-eclampsia more than one disease? BJOG. 2004;111:298-302.

D’Anna R, Baviera G, Corrado F, Giordano D, De Vivo A, Nicocia G et al. Adiponectin and insulin resistance in early- and late-onset pre-eclampsia. BJOG. 2006;113:1264-9.

Ferreira AFA, Rezende JC, Decassia R, Oliveira C, Akolekar R, Nicolaides KH. Maternal Serum Visfatin at 11-13 weeks gestation in preeclampsia. J Human Hypertens. 2013;27:261-4.

Tavana Z, Madadi G, Zolghadri J. The relationship between maternal serum visfatin level and hypertensive disorders of pregnancy. Internet J Gynecol Obstet. 2010;15(1):11166.

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Published

2017-12-25

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Original Research Articles