A rare case of Crigler-Najjar syndrome type II with pregnancy

Rachna Chaudhary, Amit Maheshwari, . Deepmala, Virendra Tapparwal

Abstract


Crigler-Najjar syndrome (CNS) has been rarely described during pregnancy with only few case reports available in literature, CNS is expressed in two forms, CNS type I and CNS type II; Type I CNS results in severe unconjugated hyperbilirubinemia and neurological impairment in newborn and is fatal. Type II CNS results in milder unconjugated hyperbilirubinemia responding to Phenobarbital treatment with better outcome.


Keywords


Pregnancy, Hyperbilirubinemia

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References


Passuello V, Puhl AG, Wirth S, Steiner E, Skala C, Koelbl H, Kohlschmidt N. Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature. Fetal Diagn Ther. 2009;26(3):121-6.

Arora N, Chaudhary S. Pregnancy with Crigler-Najjar syndrome type-II, J Obstet Gynecol 2009;29:242-4.

Holstein A, Plaschke A, Lohse P, Egberts EH. Successful Photo and Phenobarbital therapy during pregnancy in a woman with Crigler–Najjar syndrome type-II. Scand J Gasgroenterol 2005;40:1124-6.

Smith JF, Baker JM. Crigler-Najjar disease in pregnancy. Obstet Gynecol 1194;84:670-2.

Shakuntala PN, Poornima M, Padmalatha VV, Rao SR. Successful pregnancy outcome in maternal Crigler-Najjar syndrome type-II. Online J Health Allied Scs 2012;11(3):12.