Early predictors of PIH: serum β-HCG and lipid profile

L. Shanmugavadivu, K. P. Mohona Sundari, Parimala Devi


Background: The objective of the study was to evaluate β-HCG and lipid profile in early second trimester and analyse whether these parameters can be used as predictors of PIH.

Methods: 180 antenatal women in second trimester (14-20 weeks) attending antenatal clinic were taken as study population. Serum triglycerides, total cholesterol, LDL, VLDL, HDL, β-hCG was measured. All patients were followed till delivery and observed for development of PIH. Results was evaluated and analysed statistically.

Results: Out of 180 cases, 173 cases were evaluated. Among 173 cases, 87.86% were normotensive. 8.09% developed mild PIH and 4.05% developed severe PIH. There was significant increase in values of β-hCG (p<0.001) and total cholesterol, triglycerides, low density lipoproteins and very low density lipoprotein (p<0.001) and significant decrease in values of high density lipoprotein (p<0.001) in those women who developed PIH.

Conclusions: Measurement of all these parameters in early second trimester can help in predicting PIH. By proper follow up of these patients, early detection and better management of PIH and its complications is possible which would improve the maternal and fetal outcome.


β-HCG, Early predictors of PIH, Lipid profile, PIH

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