Advanced leiomyosarcoma of the uterus: a case report and literature review

Authors

  • Tawaqualit A. Ottun Department of Obstetrics and Gynecology, Lagos State University College of Medicine, Ikeja, Nigeria http://orcid.org/0000-0003-2486-4738
  • Taiwo O. Kuye Department of Obstetrics and Gynecology, Lagos State University College of Medicine, Ikeja, Nigeria
  • Olukayode A. Adegboyega Department of Radiology, Lagos State University College of Medicine Ikeja, Nigeria
  • Folasade D. H. Olalere Department of Obstetrics and Gynecology, Lagos State University College of Medicine, Ikeja, Nigeria
  • Omobolanle Akinbami Department of Radiology, Lagos State University Teaching Hospital, Ikeja, Nigeria
  • Oladunni Yusuf Oduyoye Department of Radiology, Lagos State University Teaching Hospital, Ikeja, Nigeria
  • Morenikeji M. Salami Department of Obstetrics and Gynaecology, Lagos State University Teaching Hospital, Ikeja, Nigeria
  • Kabiru Rabiu Department of Obstetrics and Gynecology, Lagos State University College of Medicine, Ikeja, Nigeria
  • Adeniyi A. Adewunmi Department of Obstetrics and Gynecology, Lagos State University College of Medicine, Ikeja, Nigeria

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20212197

Keywords:

Leiomyosarcoma, Leiomyoma, Uterine fibroid, Menorrhagia, Radiotherapy, Chemotherapy

Abstract

Uterine leiomyosarcoma is a rare malignancy accounting for 1-2% of uterine malignancies with an annual incidence of 0.5-7 per 100,000 women. It occurs mostly between the 5th to 7th decades of life hence found more among postmenopausal women.  The aetiology is mostly unknown however, in 0.2% of cases, it originates from sarcomatous degeneration in a pre-existing benign uterine fibroid. Leiomyosarcoma can be mistaken for uterine leiomyoma also known as the uterine fibroid.  It is an aggressive tumour that has a poor prognosis, with or without treatment. This case report aimed to report and discuss the occurrence of leiomyosarcoma as a differential diagnosis of abnormal uterine bleeding in this environment among other conditions. This will bring to the fore awareness among gynaecologists, pathologists, radiologists and oncologists that leiomyosarcoma of the uterus, though rare, should be considered in cases of menorrhagia with suspected uterine fibroid to avoid mistaking it for a diagnosis of uterine fibroid/leiomyoma. It is, therefore, imperative to consider leiomyosarcoma in a pre-menopausal and perimenopausal women diagnosed of abnormal uterine bleeding with symptomatic uterine fibroid. MRI serves as a good tool in differentiating the two pathologies.

 

Author Biography

Tawaqualit A. Ottun, Department of Obstetrics and Gynecology, Lagos State University College of Medicine, Ikeja, Nigeria

Lecturer !, Obstetrics  and Gynecology Department,Lagos  State University College Of Medicine,Ikeja Lagos.

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Published

2021-05-27

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Section

Case Reports