Study of correlation between age with incidence of endometrial cancer and histopathological type
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20212195Keywords:
Endometrial cancer, Endometrioid, Non-endometrioidAbstract
Endometrial carcinoma is one of the commonest Gynecological malignancy. Endometrioid type is the most common type associated with hyper-estrogenic state and has better prognosis. While non endometrioid type is less common, associated with elderly age and has dismal prognosis. Uterine cancer is most often observed in higher age group with average age at diagnosis of 60 years. It most often occurs in women over 50. 16 cases of endometrial carcinoma were collected from January 2018 until November 2020.The study evaluated the correlation of age with incidence and type of endometrial cancer by categorizing patients into different age groups and then analyzing them. The most affected age group was between 60-70 years and commonest type of endometrial cancer identified was Endometrioid type.
References
Balasubramaniam G, Sushama S, Rasika B. Mahantshetty. Hospital-based study of endometrial cancer survival in Mumbai, India. Asian Pacific Journal of Cancer Prevention. 2013;14(2):977-80.
Rose PG. Endometrial carcinoma. New England Journal of Medicine. 1996;335(9):640-9.
Dobrzycka B, Terlikowski SJ. Biomarkers as prognostic factors in endometrial cancer. Folia Histochemica et Cytobiologica. 2010;48(3):319-22.
Arafa M, Somja J, Dehan P. Current concepts in the pathology and epigenetics of endometrial carcinoma. Pathology. 2010;42(7):613-7.
Prat J, Gallardo A, Cuatrecasas M, Catas´us L. Endometrial carcinoma: pathology and genetics. Pathology. 2007;39(1):72-87.
Zaino RJ, Kurman R, Herbold D. The significance of squamous differentiation in endometrial carcinoma: data from a Gynecologic Oncology Group study. Cancer. 1991;68(10):2293-302.
Sherman M. Theories of Endometrial Carcinogenesis: A Multidisciplinary Approach. Mod Pathol. 2000;13:295-308.
Mutch DG. The more things change the more they stay the same. Gynecol Oncol. 2012;124:3-14.
Wilson TO, Podratz KC, Gaffey TA, Malkasian GD Jr, O’Brien PC, Naessens JM. Evaluation of unfavorable histologic subtypes in endometrial adenocarcinoma. Am J Obstet Gynecol. 1990;162:418-23.
Emons G, Fleckenstein G, Hinney B, Huschmand A, Heyl W. Hormonal interactions in endometrial cancer. Endocr Relat Cancer. 2000;7:227-42.
Hameed K, Morgan DA. Papillary adenocarcinoma of endometrium with psammoma
bodies. Histology and fine structure. Cancer. 1972;29:1326-35.
Hamilton CA, Cheung MK, Osann K, Chen L, Teng NN, Longacre TA et al. Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer. 2006;94:642-6.
Gusberg SB. Virulence factors in endometrial cancer. Cancer. 1993;71(4):1464-66.
American Society of Clinical Oncology. ASCO. Uterine cancer. Risk & prevention. 2020. https://www.cancer.net/cancer-types/uterine-cancer/risk-factors-and-prevention. Last accessed on 10th January 2021.
Leslie KK, Thiel KW, Goodheart MJ. Endometrial cancer. Obstet Gynecol Clin North Am. 2012;39(2):255-68.
Constantine GD, Kessler G, Graham S. Increased Incidence of Endometrial Cancer Following the Women's Health Initiative: An Assessment of Risk Factors. J Womens Health (Larchmt). 2019;28(2):237-43.
Alghamdi IG, Hussain II, Alghamdi MS. The incidence rate of corpus uteri cancer among females in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001-2008. Int J Womens Health. 2014;6:141-7.
Pellerin GP1, Finan MA. Endometrial cancer in women 45 years of age or younger: a clinicopathological analysis. Am J Obstet Gynecol. 2005;193(5):1640-4.
Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 1983;15(1):10-7.