A comparative study of serum calcium and magnesium levels in women with pre-eclampsia and normotensive women

Authors

  • Saloni Sethi Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Ankita Chaudhary Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Priya Sonkhya Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Premlata Mital Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Aditi Arora Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Vikash K. Kasana Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Ishita Agarwal Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20212186

Keywords:

Pre-eclampsia, Serum ionic calcium, Serum magnesium

Abstract

Background: Pre-eclampsia is transient but potentially dangerous complication of pregnancy. Despite of pre-eclampsia's prevalence and severity, the pathophysiology of this multisystem disorder is still poorly understood and its aetiology has not yet been fully elucidated. Recently, nutritional deficiency especially micronutrients deficiency is gaining prominence in the pathogenesis of pre-eclampsia. Hypocalcaemia and hypomagnesaemia have been implicated in the pathogenesis of pre-eclampsia. This study has been done to compare serum calcium and magnesium levels in women with pre-eclampsia and normotensive women and their association with severity of pre-eclampsia.

Methods: 50 women with pre-eclampsia and 50 normotensive women were included in the study and serum calcium and magnesium levels were measured. Data were analyzed.

Results: The serum ionic calcium concentration was significantly lower in the pre-eclamptic cases compared to the normotensive controls (3.34±1.35 versus 4.37±0.74, p=0.0000) similarly serum magnesium concentration was significantly lower in the pre-eclamptic cases compared to the normotensive controls (1.68±0.41 versus 1.94±0.42, p-0.002). Mean serum ionic Ca levels in severe pre-eclampsia group was significantly lower than normotensive pregnant women (p=0.0000) as well as mild pre-eclampsia group (p=0.001). Mean serum Mg in severe pre-eclampsia was significantly lower than normotensive pregnant women (p=0.0008) as well as mild pre-eclampsia group (p=0.03). Serum ionic Ca and Mg had a negative correlation with systolic and diastolic blood pressure.

Conclusions: Based on this study, measurements of serum ionic calcium and magnesium among women at risk of for pre-eclampsia may be used to predict the onset and severity of pre-eclampsia.

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Published

2021-05-27

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Original Research Articles