Comparison of efficacy of injection ferric carboxymaltose and iron sucrose in moderate anaemia in pregnancy
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20212670Keywords:
Anaemia, Ferric carboxymaltose, Iron sucrose complex, ParenteralAbstract
Background: Prevalence of anaemia in pregnant women is 14% in developed and 58-89.6% in pregnant Indian women. Parenteral iron is seems to be an option in the treatment of moderate iron deficiency anaemia which allow high doses of iron to be administered rapidly, in those who are intolerant to oral iron, have poor compliance to oral iron or gastrointestinal disorder. The objective was to compare the efficacy of newer drug, inravenous ferric carboxymaltose (FCM) with intravenous iron sucrose.
Methods: Group A were given injection FCM and group B were given injection iron sucrose. FCM was given in one or two sittings depending on iron requirement and iron sucrose was given in divided doses. Haemogram was done at baseline and on day 3 and 21 and at 12 weeks. All the observations were tabulated and analysed.
Results: The mean rise in haemoglobin values from baseline in the FCM group was 0.20±0.06 at 3rd day, 2.03±0.47 at 3 weeks, 3.86±0.53 at 12 weeks compared to iron sucrose group, which was 0.11±0.08 at 3rd day, 1.51±0.39 at 3 weeks, and 3.22±0.54 at 12 weeks, which was statistically significant and showed that the haemoglobin levels were increased more in FCM group. Target haemoglobin was achieved in 92% women in FCM group and 78% women in iron sucrose group.
Conclusions: Women in the FCM group achieved significantly higher haemoglobin level than in iron sucrose group. It was given in fewer sittings, hence was more convenient with better efficacy.
Metrics
References
World Health Organisation. The Prevalence of anemia in women. WHO: Geneva, Switzerland; 2017.
National Health Policy 2017. New Delhi: Ministry of Health and Family Welfare, Government of India; 2017. Available from: https://www.nhp.gov.in/nhpfiles/national_health_policy_2017.pdf. Accessed on 15 January 2018.
Jose A, Mahey R, Sharma JB, Bhatla N, Saxena R, Kalaivani M, et al. Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy-randomised controlled trial. BMC Pregnancy Childbirth. 2019;19(1):1-8.
Geisser P. The pharmacology and safety profile of ferric carboxymaltose (Ferinject): structure/reactivity relationships of iron preparations. Portuguese J Nephrol Hypertens. 2009;23(1):11-6.
Mahajan A, Bhagat BR, Gupta S, Mahajan B, Verma M. A comparative study of efficacy and safety of intravenous ferric carboxymaltose versus iron sucrose in the treatment of iron deficiency anaemia of pregnancy in a tertiary care hospital. Int J Reprod Contracept Obstet Gynecol. 2018;7:1938-42.
Swetha T, Yasodha S, Prabhu R. Comparative study of efficacy and safety of anaemia correction between iron sucrose versus ferric carboxymaltose in pregnancy. IOSR J Dent Med Sci. 2019;18(6):45-8.
Khan S, Gupta S. A comparative study of injection ferric carboxymaltose and iron sucrose in anaemia complicating pregnancy. Int J Contemp Med Res. 2019;6(8):H6-9.
Lunagariya M, Nakum KD, Vithal A, Patel J, Patel M. Iron sucrose versus ferric carboxymaltose: in search of better treatment option in cases of post partum iron deficiency anemia. Int J Contemp Med Res. 2018;5(1):12-6.
Verma U, Singh S, Chandra M, Chandra M, Garg R, Singh S, et al. To evaluate the efficacy and safety of single dose intravenous iron carboxymaltose verses multidose iron sucrose in postpartum cases of severe iron deficiency anemia. Int J Reprod Contracept Obstet Gynecol. 2015;4:442-6.
Downloads
Published
How to Cite
Issue
Section
