Efficacy of colposcopy technique with Pap smear and histology in screening of cervical lesions

Smitha Krishnegowda, Veena MS


Background: In India the most common genital cancer among women is carcinoma of the cervix (80%). The objective of the study is analysis of efficacy of colposcopy technique with Pap smear and histology in screening of cervical lesions.

Methods: Patients above 18 years of age with varied parity and socioeconomic status attending out-patient clinics were studied for correlation between cytology, colposcopy and colposcopically directed biopsy for a one year period.

Results: In cytology and colposcopic directed biopsy sensitivity is 81%, specificity is 95%, false positive is 4.9%, false negative is 18% and accuracy is 92%. In colposcopy and directed biopsy sensitivity is 94%, specificity is 91%, false positive is 7.4%, false negative is 5.8% and accuracy is 92.85%. Colposcopy helps to reduce false negative cases seen in cytology.

Conclusions: In our study overall incidence of CIN was 19, among them CIN1 in 9%, CIN2 in 4%, CIN3 in 4% and malignancy in 2% cases. Higher sensitivity in colposcopy and directed biopsy 94%, higher specificity 95% in cytology as compared to colposcopy. This emphasizes the use of all 3 methods Papincolaou cytology, colposcopy and histology is complementary to each other and helps to reduce false negative cases.


Carcinoma cervix, Papincolaou cytology, Colposcopy, Colposcopically directed biopsy, Cyto-histology correlation and colposcopy and colposcopic guided biopsy correlation

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