Role of TSH and O-GTT screening in pregnancy induced hypertension

Authors

  • Aruna Verma Department of Obstetrics & Gynaecology, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India
  • Monika Kashyap Department of Obstetrics & Gynaecology, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India
  • Abhilasha Gupta Department of Obstetrics & Gynaecology, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India

Keywords:

Pregnancy induced hypertension, Hypothyroidism, Gestational diabetes, Pregnancy

Abstract

Background: Objective of current study was to evaluate the prevalence of hypothyroidism and gestational diabetes in PIH patients and its impact on maternal and foetal outcome.

Methods: A case-control study of 200 antenatal women; group A - PIH, 100 and group B normotensive - 100 women was carried out. Serum TSH and O-GTT screening was done in both groups.

Results: In group A, 59% women had mild preeclampsia, 41% women had severe preeclampsia. Significantly raised TSH titre (>3 mIU/ml) was found in 36% women in group A and 9% women in group B (P value <0.0001). GDM was found in 33% women in group A and 8% women in group B (P value 0.0033).  

Conclusions: Incidence of both hypothyroidism (subclinical and clinical) and gestational diabetes is significantly high in women with PIH. 

Metrics

Metrics Loading ...

References

Kumar A, Ghosh BK, Murthy NS. Maternal thyroid hormonal status in pre-eclampsia. Indian J Med Sci. 2005 Feb;59(2):57-63.

Khaliq F, Singhal U, Arshad Z, Hossain MM. Thyroid functions in preeclampsia and its correlation with maternal age, parity, severity of blood pressure and serum albumin. Indian J Physiol Pharmacol. 1999;43(2):193-8.

Nahid Mostaghel, Tavanayanfar Elham, Neisani Samani Elham. Association of maternal hypothyroidism with preeclampsia. Iranian J Pathol. 2008;3(2):51-4.

Qublan HS, Al-Kaisi IJ, Hindawi IM, Hiasat MS, Awamleh I, Hamaideh AH, et al. Severe pre-eclampsia and maternal thyroid function. J Obstet Gynaecol. 2003 May;23(3):244-6.

Cleary-Goldman J, Malone FD, Lambert-Messerlian G, Sullivan L, Canick J, Porter TF, et al. Maternal thyroid hypofunction and pregnancy outcome. Obstet Gynaecol. 2008 Jul;112(1):85-92.

Bryson CL, Ioannou GN, Rulyak SJ, Critchlow C. Association between gestational diabetes and pregnancy induced hypertension. Am J Epidemiol. 2003 Dec;158(12):1148-53.

Schmidt MI, Duncan BB, Reichelt AJ, Branchtein L, Matos MC, Costa e Forti A, et al. Gestational diabetes mellitus diagnosed with a 2-h 75-g oral glucose tolerance test and adverse pregnancy outcome. Diabet Care. 2001 Jul;24(7):1151-5.

Suhonen L, Teramo K. Hypertension and preeclampsia in women with gestational glucose intolerance. Acta Obstet Gynecol Scand. 1993 May;72(4):269-72.

Downloads

Published

2017-01-04

How to Cite

Verma, A., Kashyap, M., & Gupta, A. (2017). Role of TSH and O-GTT screening in pregnancy induced hypertension. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 3(3), 720–723. Retrieved from https://www.ijrcog.org/index.php/ijrcog/article/view/1041

Issue

Section

Original Research Articles