Role of TSH and O-GTT screening in pregnancy induced hypertension

Aruna Verma, Monika Kashyap, Abhilasha Gupta


Background: Objective of current study was to evaluate the prevalence of hypothyroidism and gestational diabetes in PIH patients and its impact on maternal and foetal outcome.

Methods: A case-control study of 200 antenatal women; group A - PIH, 100 and group B normotensive - 100 women was carried out. Serum TSH and O-GTT screening was done in both groups.

Results: In group A, 59% women had mild preeclampsia, 41% women had severe preeclampsia. Significantly raised TSH titre (>3 mIU/ml) was found in 36% women in group A and 9% women in group B (P value <0.0001). GDM was found in 33% women in group A and 8% women in group B (P value 0.0033).  

Conclusions: Incidence of both hypothyroidism (subclinical and clinical) and gestational diabetes is significantly high in women with PIH. 


Pregnancy induced hypertension, Hypothyroidism, Gestational diabetes, Pregnancy

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Kumar A, Ghosh BK, Murthy NS. Maternal thyroid hormonal status in pre-eclampsia. Indian J Med Sci. 2005 Feb;59(2):57-63.

Khaliq F, Singhal U, Arshad Z, Hossain MM. Thyroid functions in preeclampsia and its correlation with maternal age, parity, severity of blood pressure and serum albumin. Indian J Physiol Pharmacol. 1999;43(2):193-8.

Nahid Mostaghel, Tavanayanfar Elham, Neisani Samani Elham. Association of maternal hypothyroidism with preeclampsia. Iranian J Pathol. 2008;3(2):51-4.

Qublan HS, Al-Kaisi IJ, Hindawi IM, Hiasat MS, Awamleh I, Hamaideh AH, et al. Severe pre-eclampsia and maternal thyroid function. J Obstet Gynaecol. 2003 May;23(3):244-6.

Cleary-Goldman J, Malone FD, Lambert-Messerlian G, Sullivan L, Canick J, Porter TF, et al. Maternal thyroid hypofunction and pregnancy outcome. Obstet Gynaecol. 2008 Jul;112(1):85-92.

Bryson CL, Ioannou GN, Rulyak SJ, Critchlow C. Association between gestational diabetes and pregnancy induced hypertension. Am J Epidemiol. 2003 Dec;158(12):1148-53.

Schmidt MI, Duncan BB, Reichelt AJ, Branchtein L, Matos MC, Costa e Forti A, et al. Gestational diabetes mellitus diagnosed with a 2-h 75-g oral glucose tolerance test and adverse pregnancy outcome. Diabet Care. 2001 Jul;24(7):1151-5.

Suhonen L, Teramo K. Hypertension and preeclampsia in women with gestational glucose intolerance. Acta Obstet Gynecol Scand. 1993 May;72(4):269-72.