Maternal and fetal outcome in preterm premature rupture of membrane


  • Mamta Sharma Department of Obstetrics and Gynecology, Government Medical College, Kota, Rajasthan, India
  • Monika Agrwal Department of Obstetrics and Gynecology, Government Medical College, Kota, Rajasthan, India
  • Hemavati Goudappagoudra Department of Obstetrics and Gynecology, Government Medical College, Kota, Rajasthan, India



PPROM, Morbidity, Respiratory distress, Primigravida


Background: The objective was to study the maternal and fetal outcome in women with premature rupture of membranes.

Methods: It was a prospective analytic hospital based study, study population include 100 obstetrics cases of singleton pregnancy with gestational age of 28 week to 36 week with spontaneous rupture of membranes over a period of 2 years, 100 pregnant women without PROM upto 36 completed week taken as control. Detailed clinical examination of the patient was done to see any co-morbidity. Data was collected using a performa. Detailed workup including history, general physical examination, abdominal and pelvic examination and relevant specific investigation were noted.

Results: PROM occurs more frequently in primigravida compared to that of multigravida (p=0.679). Risk factors unknown factors 71% and history of coitus 5% UTI (p=0.001) which was highly significant, incidence of LSCS were found higher in PROM than in controls (p<0.05) which was statistically significant. Out of all vaginal deliveries, percentage of patients who had spontaneous labour were 69.86%, while 30.14% were induced, 60% of cases was spontaneous out of which 51% delivered successfully vaginally and, 9% landed in cesarean section. 16% were given prostaglandin gel out of which 10% delivered successfully. 8% were augmented by oxytocin of which 6% delivered successfully and 2% landed in cesarean section. Out of 100 cases studies, 24% accounted for respiratory distress syndrome, while 6% in control group. 12% septicemia in study group (p=0.001) which was highly significant value, while conjunctivitis, neonatal jaundice (hyperbilirubinaemia) and intraventricular haemorrhage accounted for 2%, 3%, and 2% each.

Conclusions: Present study concluded that most common cause of PPROM was unknown. Most common maternal morbidity was puerperal fever and neonatal morbidity was respiratory distress. Maternal and fetal morbidity increases with increase in duration between rupture of membranes and delivery of fetus, so augmentation of labour should be done.


Simhan HN, Canvan TP. Preterm premature rupture of membranes; diagnosis, evaluation and management strategies. BJOG. 2005;112:32

Denney MJ, Cuhane FJ, Goldenberg LR. Prevention of preterm birth. Women Health. 2008;4:625-38.

Morris JM, Roberts CL, Crowther CA, Buchanan Sl, Henderson Smart DJ, Salkeld G. Protocol for the immediate delivery versus expectant care of woman with preterm prelaboure rupture of the membranes close to term (PPROMT) trail. BMC Pregnancy Childbirth. 2006;6:9.

Smith G, Rafuse C, Anand N, Brenanan B, Connors G, Crane J, et al. Prevalence, management and outcomes of preterm prelabour rupture of the membranes of women in Canada. J Obstet Gynecol Can. 2005;27:547-53.

Tahir S, Aleem M, Aziz R. Incidence and outcome of preterm premature rupture of membranes. Pak J Med Sci. 2002;18(1):26-32.

Ghazi A, Jabbar S, Siddiq MH. Preterm labour- still a challenge. Pak J Surg. 2006;22:222-6.

Charles PJ, Muriel R, Charles PJ, Rene E, Olivien C, Pascal G, et al. A prospective population based study of 598 causes of PROM between 24 and 34 weeks gestation description management and morality (Dominos Cohort). Eur J Obstet Gyreacol Reprod Biol. 2005;121:164-70.

Al QaQa K, Awaysheh FA. Neonatal outcome and prenatal antibiotics treatment in premature rupture of membranes. Pak J Med Sci. 2005;21:441-4.

Patil S, Patil V. Maternal and foetal outcome in premature rupture of membranes. IOSR J Dent Med Sci. 2014;13(12):56-81.

Diraviyam JMV, Karunakaran L. Maternal and perinatal outcome in pretermpremature rupture of membranes. Int J Reprod Contracept Obstet Gynecol. 2017;6:2498-502.

Surayapalem S, Cooly V, Salicheemala B. A study on maternal and perinatal outcome in premature rupture of membranes at term. Int J Reprod Contracept Obstet Gynecol. 2017;6:5368-72.

Kayiga H, Lester F, Amuge PM, Byamugisha J, Autry AM. Impact of mode of delivery on pregnancy outcomes in women with premature rupture of membranes after 28 weeks of gestation in a low-resource setting: a prospective cohort study. PLoS One. 2018;13(1):e0190388.

Choudhari P, Chhabra S, Kiyawat V. Evaluation of results of titanium elastic nailing system in paediatric lower extremity fractures of long bones. J Evol Med Dent Sci. 2014;3(72):15303-10.

Boskabadi H, Maamouri G, Mafinejad S. Neonatal complications related with prolonged rupture of membranes. Maced J Med Sci. 2011;4(1):93-8.






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