Prevalence of congenital anomalies in babies and associated maternal etiological factors at tertiary care hospital


  • Shahana I. Chandniwala Department of Obstetrics and Gynecology, B. J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India



Congenital anomalies, Consanguinity, Teratogens


Background: The objective of this study was to know the local prevalence of congenital anomaly and study the maternal risk factors associated with it.

Methods: Cross sectional descriptive study was carved out. All live babies were examined for presence of congenital anomalies and mother were looked for presence of socio-demographic factor.

Results: In this study of 1 year 5767 live birth took place at tertiary care centre out of which 63 babies had congenital anomalies. Therefore, prevalence of congenital anomalies at tertiary care centre was 1.08%.

Conclusions: The incidence of malformations were significantly higher in babies born to mothers over the age of 35 years and with parity 4 and above.



Jacobson J. Teratogen update: polychlorinated biphenyls. Teratology. 1997;5(55):338-47.

Birth Defects. 24 July 2011. Available from: Accessed on 1 November 2019.

Wilson JG. Environment and birth defects. Academic Press; 1973.

McHugh RK, Wigderson S, Greenfield SF. Epidemiology of substance use in reproductive-age women. Obstet Gynecol Clin North Am. 2014;41(2):177-89.

Bromley R, Weston J, Adab N, Greenhalgh J, Sanniti A, McKay AJ, et al. Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. Cochrane Database Syst Rev. 2014(10).

Barr Jr M, Cohen MM. ACE inhibitor fetopathy and hypocalvaria: the kidney-skull connection. Teratology. 1991;44(5):485-95.

Weiss CF, Glarko AJ, Weston JK. Chloramphenicol in the newborn Infant :a physiologic explanation of its toxicity when given in excessive doses. N Engl J Med. 1960;262:787.

Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Jewett T. Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders. Pediatrics. 2016;138(2).

Sullivan PM, Dervan LA, Reiger S, Buddhe S, Schwartz SM. Risk of congenital heart defects in the offspring of smoking mothers: a population-based study. J Pediatr. 2015;166(4):978-84.

Vikram D, Pushpa C. Congenital malformations in rural Maharashtra. Indian Pediatr. 2000;37(9):998-1001.

Chaturvedi P, Banerjee KS. Spectrum of congenital malformation in newborns from rural Maharastra. Indian J Pediatr. 1989;56:501-7.

Verma M, Chnetwal JM, Singh D. Congenital malformation- retrospective study of 10,000 cases. Indian J Paediatr. 1991;58:245-52.

Mathur BC, Karan S, Vijayadevi KKL. Congenital malformations in newborns. Indian Pediatr. 1975;12:179-83.

Kalra A, Kalra K, Sharma V, Singh M, Dayal RS. Congenital malformations. Indian Pediatr. 1984;24:945-50.

Choudry AR, Mukherjee M, Sharma A, Talukdar G, Ghosh PK. Study of 1,26,266 consecutive births for major congenital defects. Indian J Pediatr. 1989;56:493-9.

Patel ZM, Adhia RA, Birth defects surveillance study. Indian J Pediatr. 2005;72:489-91.






Original Research Articles