Cord blood levels of uric acid, lipid profile and HOMA-IR in pregnancy induced hypertension


  • Priyadharshini R. Department of Biochemistry, ESIC MC and PGIMSR, Bangalore, Karnataka, India
  • V. Vijayakumari Department of Biochemistry, ESIC MC and PGIMSR, Bangalore, Karnataka, India



Cord blood, Uric acid, Lipid profile, HOMA -IR, Pregnancy induced hypertension


Background: Cardiovascular diseases (CVD) is a major global health burden that results in the greatest number of deaths worldwide. Epigenetic changes induced by pregnancy related complication in umbilical cord blood may appear as a result of dysfunctional placenta and impaired maternal cardiovascular function and may cause later onset of cardiovascular diseases in offspring.

Methods: A prospective case control study was conducted at ESIC medical college, Bangalore in 100 PIH women with gestational age 37 to 40 weeks. The study aimed to find the correlation of cord blood uric acid, lipid profile and HOMA -IR in gestational hypertension mothers.

Results: We found a strong positive correlation between uric acid and total cholesterol in cases and a moderate positive correlation among uric acid and LDL in cases whereas a strong negative correlation among uric acid and HDL. In addition, mean HOMA-IR value was statistically significant in cases.

Conclusions: HOMA -IR values are found to be more in newborns of PIH mothers and cord blood uric acid is a good predictor of lipid metabolism and the glucose homeostasis in neonates.


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Original Research Articles