Cord blood levels of uric acid, lipid profile and HOMA-IR in pregnancy induced hypertension

Authors

  • Priyadharshini R. Department of Biochemistry, ESIC MC and PGIMSR, Bangalore, Karnataka, India
  • V. Vijayakumari Department of Biochemistry, ESIC MC and PGIMSR, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20214639

Keywords:

Cord blood, Uric acid, Lipid profile, HOMA -IR, Pregnancy induced hypertension

Abstract

Background: Cardiovascular diseases (CVD) is a major global health burden that results in the greatest number of deaths worldwide. Epigenetic changes induced by pregnancy related complication in umbilical cord blood may appear as a result of dysfunctional placenta and impaired maternal cardiovascular function and may cause later onset of cardiovascular diseases in offspring.

Methods: A prospective case control study was conducted at ESIC medical college, Bangalore in 100 PIH women with gestational age 37 to 40 weeks. The study aimed to find the correlation of cord blood uric acid, lipid profile and HOMA -IR in gestational hypertension mothers.

Results: We found a strong positive correlation between uric acid and total cholesterol in cases and a moderate positive correlation among uric acid and LDL in cases whereas a strong negative correlation among uric acid and HDL. In addition, mean HOMA-IR value was statistically significant in cases.

Conclusions: HOMA -IR values are found to be more in newborns of PIH mothers and cord blood uric acid is a good predictor of lipid metabolism and the glucose homeostasis in neonates.

References

World Health Organisation, Global report on Diabetes. Switzerland (Geneva). WHO. 2016. Available at: http://www.who.int. Accessed on 02 June 2021.

Amini E, Sheikh M, Hantoushzadeh S, Shariat M, Abdollahi A. Maternal hyperuricemia in normotensive singleton pregnancy, a prenatal finding with continuous perinatal and postnatal effects, a prospective cohort study. Biomed Central. 2014;14:104.

Ali N, Rahman S, Islam S, Haque T, Molla NH. The relationship between serum uric acid and lipid profile in Bangladeshi adults. BioMed Central. 2019;19:42.

Escendero C, Bertoglia P, Munoz F, Roberts JM. Uric acid and purine plasma levels as plausible markers for placental dysfunction in reeclampsia. 2013;14(7):895-902.

Hronadnikova I, Kotlabova K, Ivankova K, Vedmetskaya Y, Krofta L. Profiling of cardiovascular and cerebrovascular diseases associated microRNA expression in umbilical cord blood in gestational hypertension, preeclampsia and fetal growth restriction. International Journal of Cardiology. 2017;249:402-9.

Kenchappa Y, Bechera N. Assay of neonatal cord blood lipid lipid level and its correlation with neonatal gestational age, gender and birth weight: a single centre experience. International Journal Contemporary Pediatrics. 2016;3:12-4.

Kaur K, Thapar K, Malhotra P. Cord blood lipid profile comparison of newborns of hypertensive mothers. Indian Journal of Contemporary Pediatrics. 2020;7(5):1038-42.

Rodie VA, Caslake MJ, Stewart F, Sattar N, Ramsay JE, Greer IA et al. Fetal cord plasma lipoprotein status in uncomplicated human preganancies and in pregnancies complicated by Preeclampsia and Intrauterine growth restriction. Atheroscler. 2004;176(1):181-7.

Aketayeb SMH, Dehdashtian M, Aminzadeh M, Moghaddam ARE, Mortazavi M. Correlation between umbilical cord blood lipid profile and neonatal birth weight. Pediatria Polska. 2013;88:521-5.

Wang J, Shen S, Price MJ, Lu J, Sumilo D. Glucose, Insulin and Lipids in Cord Blood of neonates and their association with birthweight: Differential metabolic risk of Large for gestational age and smaller for gestational age babies. The Journal of Pediatrics. 2020;1-9.

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Published

2021-11-25

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Original Research Articles