Pregnancy and perinatal outcomes in women with polycystic ovarian syndrome
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20214337Keywords:
Gestational diabetes mellitus, Neonatal outcomes, Preeclampsia, Polycystic ovarian syndromeAbstract
Background: To study the pregnancy and perinatal outcomes in women with PCOS with normal women and to study the incidence of complications like menstrual irregularities, mode of conception, gestational diabetes mellitus, pre eclampsia, preterm labour and NICU admissions in women with PCOS.
Methods: It was prospective comparatives study done in 100 women to compare outcome in pregnancy with PCOS and normal women. A detailed history, general and obstetric examination, antenatal investigations, routine dating scan, glucose challenge test at 24 to 28 weeks in study and control groups, blood pressure recording and urine for proteinuria after 20 weeks to evaluate preeclampsia. After delivery, birth weight and APGAR score at 1 and 5 minutes were recorded. Body mass index was calculated and pregnancy outcome studied and compared.
Results: Out of 50 women with PCOS 13 developed GDM, 10 developed pre eclampsia, 6 had abortion, 4 went into preterm labour. 15 babies required NICU admission.
Conclusions: Pregnancy complications like GDM, pre eclampsia, preterm labour, abortions and neonatal complications like NICU admissions are higher in women with PCOS when compared with normal women. Hence PCOS needs to be diagnosed early and treated accordingly to prevent pregnancy complications.
References
Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89:2745-9.
Franks S. Polycystic ovary syndrome. N Engl J Med. 1995;333:853-61.
Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 1935;29:181-91.
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19-25.
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41-7.
Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 2012;97(1):28-38.
Katulski K, Czyzyk A, Podfigurna-Stopa A, Genazzani AR, Meczekalski B. Pregnancy complications in polycystic ovary syndrome patients. Gynecol Endocrinol. 2015;31(2):87-91.
Falbo A, Rocca M, Russo T, D’Ettore A, Tolino A, Zullo F, et al. Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome (PCOS): relationships with adverse outcomes. J Ovarian Res. 2010;3(1):1-8.
Yu FH, Chen HS, Rao DP, Gong J. Association between polycystic ovary syndrome and the risk of pregnancy complications; a PRISMA-compliant systematic review and meta-analysis. Medicine. 2016;95:51.
Xiao Q, Cui YY, Lu J, Zhang GZ, Zeng L. Risk for gestational diabetes mellitus and adverse birth outcomes in Chinese women with polycystic ovary syndrome. Int J Endocrinol. 2016;2016:1-6.
Roos N, Kieler H, Sahlin L, Ekman-Ordeberg G, Falconer H, Stephansson O. Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study. BMJ. 2011;343.
Anwary SA, Alfazzaman M, Begum N. A clinical study on PCOS patients in a tertiary hospital. Med Today. 2009;22(1):34-7.
Wang JX, Davies MJ, Norman RJ. Polycystic ovarian syndrome and the risk of spontaneous abortion following assisted reproductive technology treatment. Hum Reprod. 2001;16(12):2606-9.
Yan X, Shi Y, Sheng Y, Tang R, Xu L, Li Y, et al. Pregnancy outcomes of patients with polycystic ovary syndrome undergoing in vitro fertilization and embryo transfer. Chin J Obstet Gynecol. 2011;46:923-7.
Mikola M, Hiilesmaa V, Halttumen M, Suhomen L, Tiitinen A. Obsteric outcome in women with polycystic ovarian syndrome. Hum Reprod. 2001;16:226-9.
Bjercke S, Dale PO, Tanbo T, Storeng R, Ertzeid G, Abyholm T. Impact of insulin resistance on pregnancy complications and outcome in women with polycystic ovary syndrome. Gynecol Obstet Invest. 2002;54:94-8.
Boomsma CM, Eijkemans MJ, Hughes EG, Visser GH, Fauser BC, Macklon NS. A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Hum Reprod Update. 2006;12(6):673-83.
