Seroprevalence of rubella in pregnant women
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20214651Keywords:
Congenital rubella syndrome, Rubella, Rubella containing vaccine, SeroprevalenceAbstract
Background: Rubella is a droplet infection characterized by self-limiting illness. However infection during pregnancy may result in miscarriage, congenital birth defects leading to long term morbidity. The aim of the study was to estimate the seroprevalence of rubella immunity in pregnant women.
Methods: Antenatal patients, irrespective of period of gestation, fulfilling the inclusion criteria were tested for rubella IgG antibodies.
Results: A total of 258 pregnant women were included in the study. The estimated seroprevalence of immunity against Rubella infection was 70.5% (n=182) whereas 29.5% (n=76) were seronegative and thus susceptible to rubella infection. The distribution of seroprevalence of rubella immunity based on age group and gravidity were also evaluated.
Conclusions: The results reveal high level of rubella sero positivity, which indicates continued transmission of rubella infection in the community.
Metrics
References
World Health Organization, Regional office for South-East Asia. Strategic Plan for Measles Elimination and Rubella and Congenital Rubella Syndrome Control in the South-East Asia Region 2014-2020. Available from: https://apps.who.int/iris/handle/10665/205923. Accessed on 2 April 2021.
Centers for Disease Control and Prevention (CDC) (2010) Progress toward control of rubella and prevention of congenital rubella syndrome worldwide. Morb Mortal Week Rep. 2009;59:1307-10.
Cutts FT, Robertson SE, Diaz-Ortega JL, Samuel R. Control of rubella and congenital rubella syndrome (CRS) in developing countries, part 1: burden of disease from CRS. Bull World Health Organ. 1997;75:55-68.
Rubella vaccines: WHO position paper. Week Epidemiol Rec. 2011;86(29):301-16.
Yadav S, Gupta S, Kumari S. Sero-prevalence of rubella in women of reproductive age group. Indian J Pathol Microbiol. 1995;38(2):139-42.
Taneja DK, Sharma P. Targeting rubella for elimination. Indian J Public Health. 2012;56(4):269-72.
Pooja D, Piyush G. Burden of congenital rubella syndrome (CRS) in India: a systematic review. Indian Pediatr. 2012;49(5):377-99.
Gupta E, Dar L, Broor S. Seroprevalence of rubella in pregnant women in Delhi, India. Indian J Med Res. 2006;123:833-5.
Singh MP, Arora S, Das A, Mishra B, Ratho RK. Congenital rubella and cytomegalovirus infections in and around Chandigarh. Indian J Pathol Microbiol. 2009;52:46-8.
Gupta A, Jain P, Jain A. Sero-prevalence of rubella virus antibodies in pregnant women in the vicinity of Luck now, Uttar Pradesh. Arch Med. 2015;7(3):7.
Jayakrishnan T, Murkoth A, George B, Rao B, Vidya K. Sero prevalence of rubella immunity in pregnant women in Kerala, India. Int J Med Public Health. 2016;6(4):189-92.
Muliyil DE, Singh P, Jois SK, Otiv S, Suri V, Varma V, et al. Sero-prevalence of rubella among pregnant women in India, 2017. Vaccine. 2018;36(52):7909-12.
Lambert N, Strebel P, Orenstein W, Icengelo J, Poland G. Rubella. Lancet. 2015;385(9984):2297-307.
Banatwala J, Brown D. Rubella. Lancet. 2004;363(9415):1127-37.
Rubella vaccines: WHO position paper. Week Epidemiol Rec. 2000,75(20):161-9.
Muhrekar M, Verma S, Singh K, Bavdekar A, Benakappa N, Santhanam S, et al. Epidemiology of congenital rubella syndrome (CRS) in India, 2016-18, based on data from sentinel surveillance. PLoS Negl Trop Dis. 2020;14(2):e0007982.
Winter AK, Pramanik S, Lessler J, Ferrari M, Grenfell BT, Metcalf CJE. Rubella vaccination in India: identifying broad consequences of vaccine introduction and key knowledge gaps. Epidemiol Infect. 2018;146:65-77.
Knox E. Strategy for rubella vaccination. Int J Epidemiol. 1980;9:13-23.
Ministry of Women and Child Development, Government of India. Rapid Survey on Children (2013-14): India and state factsheets, 2016. Available from: https://wcd.nic.in/acts/rapid-survey-children-rsoc-2013-14. Accessed on 2 April 2021.
Introduction of Measles. Rubella vaccine guidelines (campaign and routine immunisation)-Operational guidelines. MoHFW, Government of India; 2017.
Pandya HB, Zala P, Vala R, Vohra U, Walvekar O, Vagadia Y, et al. Seroprevalence of rubella immunity in rural pregnant women attending antenatal clinics at a tertiary care centre in Piparia, Gujarat, India. J Clin Diagn Res. 2021;15(2):DC01-4.
Downloads
Published
How to Cite
Issue
Section
