Published: 2021-11-25

Primary malignant melanoma of the nipple: a case report

Moukit Mounir, Aziz Bazine, Mohammed Rahmoune, Ismail Allilou, Bouchra Elmoubakkir, Amine Ennouhi, Omar Laghzaoui


Primary melanoma origiĀ­nating on the female nipple remains an extremely rare variant of malignant melanoma and only a few cases haves been reported in the literature. We describe a case of a patient admitted for a black pigment deposition on the left nipple. Surgical resection of the left nipple and areola with clear margins and an axillary lymph node dissection was performed confirming the diagnosis of non-invasive superficial spreading melanoma.


Melanoma, Breast, Nipple, Surgery

Full Text:



Kurul S, Tas F, Buyukbabani N, Mudun A, Baykal C, Camlica H. Different manifestations of malignant melanoma in the breast: a report of 12 cases and a review of the literature. J Clin Oncol. 2005;35:202-6.

Drueppel D, Schultheis B, Solass W, Ergonenc H, Tempfer CB. Primary malignant melanoma of the breast: case report and review of the literature. Anticancer Res. 2015;35:1709-13.

Rassouli M, Voutsadakis IA. Primary noncutaneous malignant melanoma of the breast. Breast J. 2016;22: 688-91.

Nagata Y, Yoshioka M, Uramoto H. Malignant melanoma of the nipple: A case report. J Breast Cancer. 2018;21:96-101.

Papachristou DN, Kinne D, Ashikari R, Fortner JG. Melanoma of the nipple and areola. Br J Surg. 1979; 66:287-8.

Mihm MC, Clark WH, From L. The clinical diagnosis, classification and histogenetic concepts of the early stages of cutaneous malignant melanomas. N Engl J Med. 1971;284:1078-82.

Mahmoudzadeh L, Abbasi A, Mahmodlou R, Aghayan S, Asghari R. Malignant Melanoma of the Nipple With Axillary Metastasis. JCO Oncology Practice. 2020;16:516-21.

Bendic A, Bozic M, Durdov MG. Metaplastic breast carcinoma with melanocytic differentiation. Pathol Int. 2009;59:676-80.

Balch CM, Gershenwald JE, Soong SJ. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009;27:6199-206.