Review of thyroid profile in patients with heavy menstrual bleeding in a tertiary care hospital


  • Pooja R. Department of Obstetrics and gynaecology, GGMC, Mumbai, Maharashtra, India
  • Tushar Palve Department of Obstetrics and gynaecology, GGMC, Mumbai, Maharashtra, India
  • Sneha Mutyapwar Department of Obstetrics and gynaecology, GGMC, Mumbai, Maharashtra, India
  • Payal Saha Department of Obstetrics and gynaecology, GGMC, Mumbai, Maharashtra, India



Heavy menstrual bleeding, Menorrhagia, Thyroid function


Background: Heavy menstrual bleeding (HMB) is defined as excessive menstrual blood loss which interferes with a woman's physical, social, emotional and/or material quality of life. It can occur alone or in combination with other symptoms. Thyroid hormone affects menstrual pattern. The objective of this study was to evaluate thyroid function in women with menorrhagia (HMB).

Methods: It is a type of journal article. Study design- retrospective study. The present study was conducted in the Department of obstetrics and Gynecology, cama and albess hospital, Mumbai, Maharashtra, India, from a period of January 2021 to July 2021, 51 women of reproductive age group between menarche-menopause with HMB. Quantitative determination of T3, T4 and TSH by CLIA estimated in autoanalyser.

Results: About 51 women participated in the study in which most of the subjects belong to 45-49 years of age group. Maximum patients are multipara. Commonest cause of menorrhagia is fibroid. Most females with menorrhagia are euthyroid. Most of patients with HMB are O +ve. In most of the patients, anaemia due to HMB is treated by blood transfusion.

Conclusions: Biochemical evaluation of thyroid function tests should be compulsory in all patients with menorrhagia to detect thyroid dysfunction. Most females with menorrhagia are euthyroid.


Munro MG, Critchley HO, Broder MS, Fraser IS.FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. International Journal of Gynaecology and Obstetrics. 2011;113(1):3-13.

Bacon JL. Abnormal Uterine Bleeding: Current Classification and Clinical Management. Obstetrics and Gynecology Clinics of North America. 2014;44(2):179-93.

O'Brien SH. Evaluation and management of heavy menstrual bleeding in adolescents: the role of the hematologist".Hematology. 2018;30(1):390-8.

Committee on Practice Bulletins: Gynecology. Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstetrics and Gynecology. 2013;122(1):176-85.

Rodriguez BM, Lethaby A, Farquhar C. Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding". The Cochrane Database of Systematic Reviews. 2019;9:CD000400.

Marjoribanks J, Lethaby A, Farquhar C. Surgery versus medical therapy for heavy menstrual bleeding". The Cochrane Database of Systematic Reviews. 2016;(1):CD003855.

Davey DA, Dewhurst. Text book of obstetrics and gynaecology for post graduates. 5th edn; 1990:590- 600.

Thomas R, Reid RL. Thyroid disease and reproductive dysfunctions. Obstet Gynaecol. 1987;70:789-98.

Berek JS, Adarshi EY, Hillard PA. In endocrine disorders. Novaks Gynaecology 12th edn. Williums and Wilkins, Gopson paper ltd Noida. 2001;864.

Olive D, Palter S. Reproductive Physiology. In: Berek JS, eds. Berek and Novaks Gynaecology. 14th ed Philadelphia: Lippincott Williams and Wilkins Company. 2002;161-86.

Thomas R. Reid RL. Thyroid diseases and reproductive dysfunction. Obstet Gynaecol. 1987;70:789-98.

Byna P, Siddula S, Kolli S, Shaik MV. Thyroid abnormality in perimenopausal women with abnormal uterine bleeding. Int J Res Med Sci. 2015;3(11):3250-3.

Liu Z, Doan QV, Blumenthal P, Dubois RW. A systematic review evaluating health related quality of life, work impairment and health care costs and its utilization in abnormal uterine bleeding. Value Health. 2007;10(3):183-94.

Deshmukh PY, Boricha BG, Pandey A. The association of thyroid disorders with abnormal uterine bleeding. 2015.

Gowri M, Radhika BH, Harshini V, Ramaiaha R. Role of thyroid function tests in women with abnormal uterine bleeding. Int J Reprod Contracept Obstet Gynecol. 2014;3:54-7.

Joshi JV, Bhandarkar SD, Chadha M, Balaiah D, Shah R. Menstrual irregularities and lactation failure may precede thyroid dysfuction or goitre. J Postgraduate Med. 1993;39:137-41.

Kaltsas J, Paunkovic N, Kaltsas T, Papadopoulou P, Paunkovic J. Disturbances of menstruation in hypothyroidism. Clin Endocrinol. 1999;50:655-9.






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