Angiomyofibroblastoma: a very rare tumour of vulva

Authors

  • Urvashi Verma Department of Obstetrics and Gynaecology, S. N. Medical College, Agra, Uttar Pradesh, India
  • Asha Nigam Department of Obstetrics and Gynaecology, S. N. Medical College, Agra, Uttar Pradesh, India
  • Chandrakanta . Department of Pathology, S. N. Medical College, Agra, Uttar Pradesh, India
  • Romila Chowang Department of Obstetrics and Gynaecology, S. N. Medical College, Agra, Uttar Pradesh, India
  • Sadhana Bharti Department of Obstetrics and Gynaecology, S. N. Medical College, Agra, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20220197

Keywords:

Angiomyofibroblastoma, Aggressive angiomyxoma, Aggressive angifibroma

Abstract

Angiomyofibroblastoma is a rare benign mesenchymal tumor of vulva. Patient had history of gradually increased mass over 6 years of duration. It was painless, fibro-cystic mass of 6.8×4.6×2.5 cm hanging over right side labia majora without any menstrual or coitus difficulty. Cosmetic and risk of malignancy were the main issues. After complete examination and investigations simple excision done. Histological examination revealed mass composed of numerous capillaries and some ectatic blood vessels embedded within the hyalinised matrix. No lipomatous component was found within the tumour. Nuclear atypism and pleomorphism were absent and mitotic figures were not detected. All these were suggestive of benign mesenchymal tumor, angiomyofibroblastoma.

Author Biography

Urvashi Verma, Department of Obstetrics and Gynaecology, S. N. Medical College, Agra, Uttar Pradesh, India

associate professor department of obs & gyn, S. N. Medical college Agra

References

Fletcher CD, Tsang WY, Fisher C, Lee KC, Chan JK. Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol. 1992;16:373-82.

Onckner DM, Sayadi H, SwansonPE, Ritter JH, Wick MR. Genital angiomyofibroblastoma. Comparison with aggressive angiomyxoma and other myxoid neoplasm of skin and soft tissue. Am J Clinc Pathol. 1997;107:36-44.

Fukunga M, Nomura k, Doi K Endo Y, Ushigome S. Vulvular angiomyofibroblastoma. Clinicopathologic analysis of six cases. Am J Pathol. 1997;107:45-51.

Hisaoka M, Kouho H, Aoki T, Daimaru Y, Hashimoto H. Angiofibroblastoma of the vulva. A clinicohistologic study of seven cases. Pathol Int. 1995;45:487-92.

Laskin WB, Fetsh JF, Mostofi FK. Angiofibroblastoma like tumor of the male genital tract: analysis of 11 cases with comparison to female angimyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1998;22:6-16.

Ockner DM, Sayadi H, Swanson PE, Ritter JH, Wick MR. Genital angiomyofibroblastoma. Comparison with aggressive angiomyxoma and other myxoid neoplasm of skin and soft tissue. Am J Clinc Pathol. 1997;107:36-44.

HSU IH, Chang TC, Wc CT Chen RJ, Chow SN. Angiofibroblastoma of the vulva. J Formos Med Assoc. 2004;103:467-71.

Granter SR, Nucci MR, Fletcher CDM. Aggressive angiomyxoma : reaapprasial of it’s relationship to angiomyofibroblastoma in a series of 16 cases. Histopathology. 1997;30:3-10.

Nucci MR and Fletcher CDM: Vulvovaginal soft tissue tumor: upgrade and review. Histopathology. 2000;36:97-108.

Iwasa Y, Fletcher CD. Cellular angiofibroma. Clinicopathologic and immunohistochemical analysis of 51 cases. Am J Surg Pathol. 2004;28:1426-35.

Laskin WB, Fetsh JF, Tavassoli FA. Superficial cervicovaginal myofibroblastoma. Fourteen cases of distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower genital tract. Hum Pathol. 2001;32:715-25.

Fetsh JF Laskin WB, Tavassoli FA. Superficial angiomyxoma (cutaneous myxoma). A clinic-pathologic study of 17 cases arising in the genital region. Int J Gynecol Pathol. 1997;16:325-34.

Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum. Report of 9 cases of a distinctive type of gynecolgic soft tissue neoplasm. Am J Surg Pathol. 1983;7:463-75.

Fetsch JF, Laskin WB, Lefkowitz M, Kindblom JM. Aggresssive angiomyxoma. A clinicopathologic study of 29 female patients. Cancer. 1996;78:79-90.

Geng J, Hu S, Wang F. Large paravaginal angimyofibroblastoma. Magnetic Resonance Imaging findings. Jpn J Radiol. 2011;29:152-5.

Shintaku M, Noda H, Hashimoto. Large polypoid angiomyofibroblastoma of the vulva. Int J Clinc Exp Pathol. 2018;11(11):5509-13.

Chapel DB, Bennet J. Angiofibroblastoma. Pathology. 2021;3:14-8.

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Published

2022-01-28

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Section

Case Reports