DOI: https://dx.doi.org/10.18203/2320-1770.ijrcog20215074
Published: 2021-12-28

Correlation between maternal thyroid stimulating hormone and birth weight of neonate

Nishita Shettian, Hema Venkata Naga Sai Sudha Pavuluri

Abstract


Background: The aim of this study is to determine the pregnancy outcomes in women with thyroid disorders.

Methods: This is a retrospective observational study conducted in the department of obstetrics and gynaecology of AJ institute of medical sciences and research centre from the month of March to September 2021. The first trimester thyroid stimulating hormone (TSH) level and birth weight of new born is collected from hospital records, study participants included all the pregnant mothers who were admitted and delivered in the labour ward of AJ institute of medical sciences

Results: According to our study low birth weight in neonates in euthyroid, hypothyroid, hyperthyroid participants were 21.4%, 61.5%, and 100% respectively.

Conclusions: This study indicates that there is an association between maternal thyroid levels and neonatal birth weight. A higher TSH concentration during first trimester of pregnancy is associated with low birth weight. Based on these findings, it is recommended that maternal thyroid levels be monitored closely in the first trimester and initiate timely treatment in case of altered thyroid levels during pregnancy in order to have a healthy pregnancy and healthy baby with no compromise in the fetal weight.

 


Keywords


First trimester TSH levels, Low-birth weight, SGA, Preterm, Sub clinical hypothyroidism, Hyperthyroidism

Full Text:

PDF

References


Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C et al. 2017 guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27(3):315-89.

Wiles KS, Jarvis S, Nelson-Piercy C. Are we overtreating subclinical hypothyroidism in pregnancy? BMJ. 2015;351:h4726.

Casey BM, Dashe JS, Wells E. Subclinical hypothyroidism and pregnancy outcomes. Obstet Gynecol. 2005;105(2):239-45.

Kiran Z, Sheikh A, Islam N. Maternal characteristics and outcomes affected by hypothyroidism during pregnancy. BMC pregnancy and childbirth. 2019;19:476.

World Health Organization. International statistical classification of diseases and related health problems, tenth revision, world health organization, Switzerland. 1992.

De Escobar GM, Obregon MJ, Del Rey FE. Role of thyroid hormone during early brain development. Eur J Endocrinol. 2004;151:U25-37.

Krassas GE, Poppe K, Glinoer D: Thyroid function and human reproductive health. En docr Rev. 2010;31:702-55.

Andersen SL, Olsen J, Wu CS, Laurberg P. Low Birth Weight in Children Born to Mothers with Hyperthyroidism and High Birth Weight in Hypothyroidism, whereas Preterm Birth Is Common in Both Conditions: A Danish National Hospital Register Study. Eur Thyroid J. 2013;2:135-44.

Barjaktarovic M, Korevaar TI, Chaker L, Jaddoe VW, De Rijke YB, Visser TJ et al. The association of maternal thyroid function with placental hemodynamics. Hum Reprod. 2017;32(3):653-61.

Derakhshan A, Peeters RP, Taylor PN, Bliddal S, Carty DM, Meems M et al. Association of maternal thyroid function with birth weight: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 2020;8(6):501-10.