Comparison of efficacy of 600 and 800 micrograms vaginal misoprostol in early pregnancy failure in SMGS: a tertiary health care hospital in Jammu, India

Reema Khajuria; Arushi Suri; Rohini Jaggi

doi:10.18203/2320-1770.ijrcog20220022

Authors

Reema Khajuria Department of Obstetrics and Gynaecology, SMGS, GMC, Jammu, Jammu and Kashmir, India
Arushi Suri Department of Obstetrics and Gynaecology, SMGS, GMC, Jammu, Jammu and Kashmir, India
Rohini Jaggi Department of Obstetrics and Gynaecology, SMGS, GMC, Jammu, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20220022

Keywords:

Misoprostol, Missed abortion, Early pregnancy failure

Abstract

Background: Misoprostol use in early pregnancy failure is varied and dose is not well established. Aim of this study was to compare efficacy and side effects of 600 versus 800 micrograms vaginal misoprostol in early pregnancy failure.

Methods: A randomized prospective observational study was conducted in the postgraduate department of obstetrics and gynaecology, SMGS hospital Jammu from November 2018 to October 2019 after getting approval from the ethical committee. Hundred patients (50 in group A and 50 in group B) admitted in labour room before 12 weeks of gestation with an ultrasound diagnosis of early fetal demise (missed abortion or brightened ovum) were treated medically with different doses of vaginal misoprostol.

Results: The success rate in patients in group A is 72% and group B is 88%, p=0.045 (difference is statistically significant). Patients who required suction and evacuation were 28% in group A and 12% in group B.

Conclusions: Use of misoprostol for medical management of 1^st trimester missed/anembryonic is an effective, cheap, safe and convenient alternative to surgical evacuation. It was concluded that 800 micrograms vaginal misoprostol is more effective than 600 micrograms vaginal misoprostol. But 800 micrograms misoprostol has more side effects than 600 micrograms vaginal misoprostol.

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Author Biography

Reema Khajuria, Department of Obstetrics and Gynaecology, SMGS, GMC, Jammu, Jammu and Kashmir, India

gynae and obs,senior resident

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