Effect of maternal anemia on cord blood haemoglobin of newborn
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20215076Keywords:
Cord hemoglobin, Maternal anemia, New-bornAbstract
Background: Anemia during pregnancy is linked to major maternal and fetal problems. The aim of the study was to find any correlation between maternal anemia and neonatal cord blood haemoglobin (Hb) levels.
Methods: This cross-sectional study was done in the department of pediatrics and department of obstetrics and gynaecology at the Hind Institute of Medical Sciences, Barabanki over 9 months from January 2021 to September 2021. A total of 308 pregnant females more than 34 weeks of gestation who delivered participated in the study and cord blood hemoglobin of their new-born was collected. The mean maternal hemoglobin and mean cord blood hemoglobin were compared using the Pearson correlation coefficient in different groups i.e., non-anemic, anemic, mild, moderate, and severe anemic groups.
Results: Out of 308 pregnant women, 198 (64.3%) were anemic, and 110 (35.7%) were nonanemic. The mean maternal hemoglobin among non-anemic mothers and anemic mothers was 11.91 (0.70) and 9.14 (1.56) respectively. The Pearson correlation coefficient of non-anemic, anemic, mild, moderate, and severe anemic groups were 0.6985, 0.8453, 0.7772, 0.6321, and 0.7226 respectively with a statistically significant p value<0.05 showing a positive correlation between maternal hemoglobin and cord hemoglobin.
Conclusions: From this study, we concluded that maternal anemia affects neonatal cord blood hemoglobin. According to the findings, anemic women deliver new-born with lower hemoglobin levels than non-anemic mothers. The findings revealed a linear correlation between maternal hemoglobin and cord blood hemoglobin of their new-born.
References
National Health Portal of India. Diseases/conditions information: Anaemia during pregnancy (Maternal anemia), 2021. Available at: https://www.nhp.gov.in/disease/gynaecologyandobstetrics/anaemia-during-prmaternalanemia. Accessed on 05 December 2021.
National Family Health Survey. NHFS 3 Publications Fact sheets India, 2021. Available at: http://rchiips.org/nfhs/pdf/India.pdf. Accessed on 05 December 2021.
National Family Health Survey. NHFS 4 Publications Fact sheets India, 2021. Available at http://rchiips.org/nfhs/pdf/NFHS4/India. Accessed on 05 December 2021.
National Family Health Survey. NHFS 5 Publications Fact sheets India, 2021. Available at: http://rchiips.org/nfhs/NFHS-5FCTS/India. Accessed on 05 December 2021.
WHO. Hemoglobin concentrations for the diagnosis of anemia and assessment of severity. Vitamin and Mineral Nutrition Information System, 2011. Available at: https://www.who.int/vmnis/indicators/haemoglobin.pdf. Accessed on 05 December 2021.
Jung J, Rahman MM, Rahman MS, Swe KT, Islam MR, Rahman MO, et al. Effects of hemoglobin levels during pregnancy on adverse maternal and infant outcomes: a systematic review and meta-analysis. Ann N Y Acad Sci. 2019;1450(1):69-82.
Breymann C, Bian XM, Capito LR, Chong C, Mahmud G, Rehman R. Expert recommendations for the diagnosis and treatment of iron-deficiency anemia during pregnancy and the postpartum period in the Asia-Pacific region. J Perinat Med. 2011;39(2):113-21.
Rajendran R, Suman FR, Sudheer Raj RS, Rajesh Kanna P, Borra NR. Umbilical Cord Blood Hemogram: What Is the Effect of Maternal Anemia?. Blood. 2015;126(3):4536.
Shukla AK, Srivastava S, Verma G. Effect of maternal anemia on the status of iron stores in infants: A cohort study. J Family Community Med. 2019;26(2):118-22.
Bernhardt GV, Jhancy M, Shivappa P, Bernhardt K, Pinto JR. Relationship between Maternal and Cord Blood Iron Status in Women and their New Born Pairs. Biomedical and Pharmacol J. 2021;14(1):317-23.
Kohli UA, Rajput M, Venkatesan S. Association of maternal hemoglobin and iron stores with neonatal hemoglobin and iron stores. Med J Armed Forces India. 2021;77(2):158-64.
Kant S, Kaur R, Goel AD, Malhotra S, Haldar P, Kumar R. Anemia at the time of delivery and its association with pregnancy outcomes: A study from a secondary care hospital in Haryana, India. Indian J Public Health. 2018;62(4):315-8.
Klebanoff MA, Shiono PH, Selby JV, Trachtenberg AI, Graubard BI. Anemia and spontaneous preterm birth. Am J Obstet Gynecol. 1991;164(1):59-63.
Klebanoff MA, Shiono PH, Selby JV, Trachtenberg AI, Graubard BI. Anemia and spontaneous preterm birth. Am J Obstet Gynecol. 1991;164(1):59-63.
Prasad SG. Relationship between gravida status and severity of anemia? Int J Med Sci Educ. 2019;6(4):81-4.
Tembhare A, Shelke S, Shivkumar PV, Tayade S. Iron deficiency anemia in pregnant mothers as a cause of poor maternal health in rural India. Endocrinology. 2015;3(2)128-37.
Figueiredo ACMG, Filho IS, Batista JET, Orrico GS, Porto ECL, Cruz PRM, et al. Maternal anemia and birth weight: A prospective cohort study. PLoS One. 2019;14(3):212817.
Timilsina S, Karki S, Gautam A, Bhusal P, Paudel G, Sharma D. Correlation between maternal and umbilical cord blood in pregnant women of Pokhara Valley: a cross sectional study. BMC Pregnancy Childbirth. 2018;18(1):70.
Sareen A, Singh S, Mahajan K. Maternal Anemia and its Effect on Cord Hemoglobin. Paediatr Rev Int J Paediatr Res. 2018;5(7):351-4.
Najeeba CM, Prabhu AS, Saldanha PR. Maternal anemia and its effect on cord blood hemoglobin and newborn birth weight. IOSR J Dent Med Sci. 2015;14(7):30-2.
Debbarma R, Debbarma B, Devi MA. Effect of maternal anaemia on cord haemoglobin and birth weight of newborns. IOSR J Med Sci. 2015;14(7):19-21.
Mamoury GH, Hamedy AB, Akhlaghi F. Cord hemoglobin in newborns in correlation with maternal hemoglobin in northeastern Iran. Iranian J Med Sci. 2015;28(4):166-8.
