Study of the frequency of female genital tract infection using cartridge based nucleic acid amplification test

Drishti Chaudhary; Mamta Tyagi; Smriti Gupta; Lalita Yadav; Anita Pandey

doi:10.18203/2320-1770.ijrcog20220063

Authors

Drishti Chaudhary Department of Obstetrics and Gynecology, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India http://orcid.org/0000-0003-0290-6837
Mamta Tyagi Department of Obstetrics and Gynecology, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
Smriti Gupta Department of Obstetrics and Gynecology, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
Lalita Yadav Department of Obstetrics and Gynecology, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
Anita Pandey Department of Microbiology, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20220063

Keywords:

CBNAAT, Tuberculosis, Tubercle bacilli

Abstract

Background: The aim of the study was to study the frequency of female genital tract infection using cartridge based nucleic acid amplification test (CBNAAT), to study the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of CBNAAT.

Methods: This prospective observational study was conducted among 100 patients as per inclusion criteria with genital tract infection in Swami Vivekanand Subharti University, Meerut over a period of two years. Investigations including ZN staining for acid fast bacillus (AFB), endometrial sampling for histopathology, CBNAAT and BACTEC culture were sent.

Results: In a study of 100 patients’ histopathological examination detected tuberculosis in 2% patients while CBNAAT detected tuberculosis in 5% patients. Tubercle bacilli was found in 3% women on AFB stain while in only 1%-woman genital tuberculosis was diagnosed by BACTEC culture.

Conclusions: Female genital tuberculosis is detected most frequently when a woman presents with unexplained infertility. Newer technologies allow genital tuberculosis to be identified at an earlier stage and enable us to provide treatment. CBNAAT being a sensitive test picked up more cases than histopathology, culture, AFB stain. Hence CBNAAT should be widely used for early detection of female genital tuberculosis.

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Author Biography

Drishti Chaudhary, Department of Obstetrics and Gynecology, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India

Junior resident obs and gyne department

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