Ovarian hyper stimulation syndrome in a spontaneous singleton pregnancy: a case report

Anuj Kumar Sharma, Radha Rastogi, Kalpesh Patel, K. G. Vivek


Ovarian hyper stimulation syndrome (OHSS) is extremely rare in spontaneous pregnancies. Spontaneous OHSS can result from glycoprotein hormones stimulating follicle-stimulating hormone receptors (FSHR). Our case reinforces the importance of a prompt diagnosis and management in all pregnant patients presenting with acute abdomen and ovarian masses. We report a case of spontaneous singleton pregnancy at 12-week POG presented with abdominal distension and enlarged ovaries. Patient was successfully managed with supportive treatment comprise of intravenous (IV) Albumin, thromboprophylaxis, dopamine agonist and insulin sensitizer. Spontaneous OHSS should be included in the differential diagnosis of acute abdomen in pregnant women. Since spontaneous OHSS can be associated with life-threatening complications, it requires early diagnosis for successful management. The etiology should be determined in order to focus the treatment and avoid future complications.



Secondary OHSS, Thromboprophylaxis, hCG, GnRH analogues, Dopamine agonist

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