DOI: https://dx.doi.org/10.18203/2320-1770.ijrcog20220035
Published: 2022-01-28

Low dose magnesium sulphate regimen and maternal outcome of patients with eclampsia

Palvi Banotra

Abstract


Background: Preeclampsia, a serious pregnancy complication which is commonly characterized by high blood pressure, presence of protein in the urine and sometimes swelling in women's feet, legs and hands. With this condition, patient’s high blood pressure often results in seizures. Generally, the outcome remains good, however, eclampsia can be life threatening and disastrous.

Methods: This cross-sectional study considered 114 patients who meet inclusion criteria and agreed to will-fully participate in the study were evaluated for different parameters. Patients who developed eclampsia during intra-natal and postnatal period were included in the study. The aim of the study was to evaluate the maternal outcome among all patients of eclampsia treated with low magnesium sulphate dosage therapy.  

Results: The present study revealed, very low fit recurrence rate, low mortality rate, zero treatment failure rate, no toxicity and (99.12%) success rate.

Conclusions: Apart from zero percent treatment failure rate, Low maternal mortality and fit recurrence rate encouraged us to continue the treatment with low dose MGSO4 regimen. Thus, low dose magnesium sulphate has been found very effective in treating the eclampsia and at the same time maintains the high safety margin.


Keywords


Preeclampsia, Eclampsia, Magnesium sulphate

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References


Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33(3):130-7.

The Eclampsia Trial Collaborative Group. Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet. 1995;345(8963):1455-63.

Sibai BM. Magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia. Am J Obstet Gynecol. 1990;162(5):1141-5.

Pritchard JA, Cunningham FG, Pritchard SA. The Parkland Memorial Hospital protocol for treatment of eclampsia: evaluation of 245 cases. Am J Obstet Gynecol. 1984;148(7):951-63.

Roberts JM. Magnesium for preeclampsia and eclampsia. N Engl J Med. 1995;333(4):250-1.

Nagar S, Jain S, Kumari S. Reassessment of therapy of eclampsia: comparison of mortality and morbidity of mother and foetus with parenteral magnesium sulphate and lytic cocktail therapy. J Obstet Gynaecol India. 1988;38:250-5.

Pritchard JA, Cunningham FG, Pritchard SA. The Parkland Memorial Hospital protocol for treatment of eclampsia: evaluation of 245 cases. Am J Obstet Gynecol. 1984;148(7):951-63.

Sibai BM. Eclampsia. VI. Maternal-perinatal outcome in 254 consecutive cases. Am J Obstet Gynecol. 1990;163(3):1049-54.

Seth S, Nagrathi A, Singh DK. Comparison of low dose, single loading dose and standard Pritchard regimen of magnesium sulfate in antepartum eclampsia. Anatol J Obstet Gynecol. 2010;1:1-4.

Kumar S, Kumar S, Kumar D, Gupta A, Gupta S. Maternal Outcome in Eclampsia with Low Dose Magnesium Sulphate Therapy. JK Sci. 2017;17(4):196-9.

Regmi MC, Aggrawal A, Pradhan T, Rijal P, Subedi A, Uprety D. Loading dose versus standard regimen of magnesium sulphate in eclampsia--a randomized trial. Nepal Med Coll J. 2010;12(4):244-7.

Sardesai S, Maira S, Patil A. Low dose magnesium sulphate therapy for eclampsia and imminent eclampsiaregime tailored for Indian women. J Obstet Gynaecol India. 2003;56:546-50.