Comparison of different treatments used for polycystic ovary syndrome

Authors

  • Miriam C. Llamas School of Medicine, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México http://orcid.org/0000-0002-7693-9773
  • Javier Méndez Montejano School of Medicine, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México
  • Maritza Del C. Mudarra Vergara Medicine Program, Academic Unit Health Sciences, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México
  • Aldhara Z. Cordero Muñoz School of Medicine, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México
  • María G. Ramírez Vargas School of Medicine, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México
  • Andrea Lira Otero School of Medicine, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México
  • Luis A. Pineda Martínez School of Medicine, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México
  • José M. Zepeda Torres School of Medicine, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, México
  • Miriam C. Pérez Díaz School of Medicine, Universidad del Valle de México, Zapopan, Jalisco, México

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20220207

Keywords:

Polycystic ovary syndrome, Treatment, Comparison, Hyperandrogenism

Abstract

Polycystic ovary syndrome (PCOS) is a disease that currently affects many women of reproductive age. In recent years, the incidence of PCOS has increased, affecting 4% of all women worldwide, with a prevalence of 6% in Mexico. PCOS is a condition characterized by different metabolic, reproductive and hormonal disorders such as hyperandrogenism, chronic anovulation, menorrhagia or infertility. Patients commonly develop clinical alterations such as hirsutism, acne and in some cases, they become overweight or obese. Different medications and therapeutic methods from different literatures were evaluated, both pharmacological such as inositol, metformin, resveratrol, simvastatin, dapagliflozin, which showed great improvement, decreasing the levels of hyperandrogenism in patients, as well as non-pharmacological, of which significant improvements were found with a change in lifestyle, such as exercise, ketogenic diet and herbal medications such as chamomile and cinnamon, which showed a positive change in patients. It is important to make a diffusion and early diagnosis of PCOS, since in this way it will be possible to have a timely treatment, which can be individualized according to the characteristics and needs of each patient.

Metrics

Metrics Loading ...

References

Borzoei A, Rafraf M, Niromanesh S, Farzadi L, Narimani F, Doostan F. Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome. J Tradition Complement Med. 2018;8(1):128-33.

Ibáñez L, Díaz M, García-Beltrán C, Malpique R, Garde E, López-Bermejo A, et al. Toward a treatment normalizing ovulation rate in adolescent girls with polycystic ovary syndrome. J Endocrine Soc. 2020;4(5):1-9.

Hoffman B, Schorge J, Halvorson L, Hamid C, Corton M, Schaffer J. Williams-Ginecología. 4th ed. McGraw Hill; 2020.

Pani A, Gironi I, DiVieste G, Mion E, Bertuzzi F, Pintaudi B. From prediabetes to type 2 diabetes mellitus in women with polycystic ovary syndrome: lifestyle and pharmacological management. Int J Endocrinol. 2020;2020:1-10.

Jameson J, Fauci A, Kasper D, Hauser S, Longo D, Loscalzo J. Harrison-Principios de Medicina Interna. 20th ed. McGraw Hill; 2018.

Abdel-Maboud M, Menshawy A, Hasabo E, Abdelraoof M, Alshandidy M, Eid M, et al. The comparative effectiveness of 55 interventions in obese patients with polycystic ovary syndrome: A network meta-analysis of 101 randomized trials. Plos One. 2021;16(7):1-31.

Fraser G, Obermayer-Pietsch B, Laven J, Griesinger G, Pintiaux A, Timmerman D, et al. Randomized controlled trial of neurokinin 3 receptor antagonist fezolinetant for treatment of polycystic ovary syndrome. J Clin Endocrinol Metabol. 2021;106(9):3519-32.

dos Santos I, Ashe M, Cobucci R, Soares G, Maranhão T, Dantas P. The effect of exercise as an intervention for women with polycystic ovary syndrome. Medicine. 2020;99(16):1-11.

Pundir J, Psaroudakis D, Savnur P, Bhide P, Sabatini L, Teede H, et al. Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. Int J Obstetr Gynaecol. 2017;125(3):299-308.

Vanhauwaert P. Síndrome de ovario poliquístico e infertilidad. Revista Médica Clínica Las Condes. 2021;32(2):166-72.

Kite C, Lahart I, Afzal I, Broom D, Randeva H, Kyrou I, et al. Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis. Systemat Rev. 2019;8(1):1-28.

Akbarzadeh M, Heidary M, Yazdanpanahi Z, Dabbaghmanesh M, Parsanezhad M, Emamghoreishi M. Effect of chamomile capsule on lipid- and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome. J Res Med Sci. 2018;23(1):1-7.

Brenjian S, Moini A, Yamini N, Kashani L, Faridmojtahedi M, Bahramrezaie M, et al. Resveratrol treatment in patients with polycystic ovary syndrome decreased pro‐inflammatory and endoplasmic reticulum stress markers. Am J Reproduct Immunol. 2019;83(1):1-10.

Corrie L, Gulati M, Vishwas S, Kapoor B, Singh S, Awasthi A, et al. Combination therapy of curcumin and fecal microbiota transplant: potential treatment of polycystic ovarian syndrome. Med Hypotheses. 2021;154:1-5.

Jazani AM, Azgomi HND, Azgomi A, Azgomi R. A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS). DARU J Pharmaceut Sci. 2019;27(2):863-77.

Mihanfar A, Nouri M, Roshangar L, Khadem-Ansari M. Polyphenols: natural compounds with promising potential in treating polycystic ovary syndrome. Reproduct Biol. 2021;21(2):1-11.

Meng J, Zhu Y. Efficacy of simvastatin plus metformin for polycystic ovary syndrome: a meta-analysis of randomized controlled trials. Eur J Obstetr Gynecol Reproduct Biol. 2021;257:19-24.

Heidari B, Lerman A, Lalia A, Lerman L, Chang A. Effect of metformin on microvascular endothelial function in polycystic ovary syndrome. Mayo Clinic Proceeding. 2019;94(12):2455-66.

Rezk M, Shaheen A, El-Nasr IS. Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial. Gynecolog Endocrinol. 2017;34(4):298-300.

Kostopoulou E, Anagnostis P, Bosdou J, Spiliotis B, Goulis D. Polycystic ovary syndrome in adolescents: pitfalls in diagnosis and management. Curr Obes Rep. 2020;9(3):193-203.

Woo J, Long J. Diagnóstico Clínico y Tratamiento 2021. 60th ed. McGraw Hill; 2021.

Creanga A, Bradley H, McCormick C, Witkop CT. Use of metformin in polycystic ovary syndrome. Obstetr Gynecol. 2008;111(4):959-68.

Løvvik T, Carlsen S, Salvesen Ø, Steffensen B, Bixo M, Gómez-Real F, et al. Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. Lancet Diabet Endocrinol. 2019;7(4):256-66.

Debras E, Fernandez H, Neveu M, Deffieux X, Capmas P. Ovarian drilling in polycystic ovary syndrome: long term pregnancy rate. Eur J Obstetr Gynecol Reproduct Biol. 2019;4:1-7.

Con exitoso tratamiento para ovario poliquístico en el IMSS, derechohabiente logró ser madre. IMSS-Unidad de Comunicación Social. 2019;(324):1-2.

Ünal D, Demirci H, Yılmaz M, Kısa Ü, Tulmaç M, Güliter S. The effects of metformin, ethinyl estradiol/cyproterone acetate, and metformin ethinyl estradiol/cyproterone acetate combination therapy on carotid artery intima-media thickness in patients with polycystic ovary syndrome. Istanbul Med J. 2020;21(1):47-52.

Behboudi-Gandevani S, Abtahi H, Saadat N, Tohidi M, Ramezani Tehrani F. Effect of phlebotomy versus oral contraceptives containing cyproterone acetate on the clinical and biochemical parameters in women with polycystic ovary syndrome: a randomized controlled trial. J Ovarian Res. 2019;12(1):1-9.

Ghanei N, Rezaei N, Amiri G, Zayeri F, Makki G, Nasseri E. The probiotic supplementation reduced inflammation in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. J Function Food. 2018;42:306-11.

Paoli A, Mancin L, Giacona M, Bianco A, Caprio M. Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J Translation Med. 2020;18(1):1-11.

Muñoz M. Síndrome de Ovario Poliquístico (SOP). Revista de Formación Continuada de la Sociedad Española de Medicina de la Adolescencia. 2016;4(2):20-31.

Azziz R. Polycystic ovary syndrome. Obstetr Gynecol. 2018;132(2):321-36.

Sharma A, Welt C. Practical approach to hyperandrogenism in women. Med Clin North Am. 2021;105(6):1099-116.

Lee J, Jo J. Successful treatment with Korean herbal medicine and lifestyle management in an obese woman with polycystic ovarian syndrome. Integrat Med Res. 2017;6(3):325-8.

Oberai P, Lamba C, Manchanda R, Rath P, Bindu H, Padmanabhan M. Evaluation of homoeopathic treatment in polycystic ovary syndrome: a single-blind, randomised, placebo-controlled pilot study. Indian J Res Homoeo. 2018;12(1):35-45.

Al-Bayyari N, Al-Domi H, Zayed F, Hailat R, Eaton A. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: a randomized placebo controlled clinical trial. Clin Nutrit. 2021;40(3):870-8.

George M, Joseph L, Chacko B, Reji N. A prospective study on the effectiveness of metformin and ethinyl estradiol-cyproterone acetate in the management of hyperandrogenism in polycystic ovary syndrome patients. World J Pharmaceut Res. 2018;7(16):1165-81.

Zhang J, Bao Y, Zhou X, Zheng L. Polycystic ovary syndrome and mitochondrial dysfunction. Reproduct Biol Endocrinol. 2019;17(1):1-15.

Downloads

Published

2022-01-28

Issue

Section

Review Articles