Published: 2022-02-25

Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in pregnancy in a known case of antiphospholipid antibody syndrome

Nitin Pai Dhungat, Shubhdeep Kaur


Thrombotic thrombocytopenic purpura is a haematological disorder which may be severely life-threatening. It affects the microcirculation of multiple organ systems. One of the precipitating factors for thrombotic thrombocytopenic purpura is pregnancy. The case report describes a 32 years old patient who presented with antepartum TTP-HUS and was initially treated as a case of HELLP syndrome without any improvement. The introduction of aggressive treatment with plasma transfusion and plasmapheresis has improved maternal and fetal survival rates in these cases. thrombotic thrombocytopenic purpura-haemolytic uremic syndrome is a rare complication of pregnancy and parturition, that may simulate the more common obstetric complications, namely, preeclampsia and the syndrome of haemolysis, elevated liver functions tests, low platelets. Review of the previously reported cases of pregnancy-related TTP and the current treatment options for this rare condition are also discussed. Careful diagnosis, monitoring, and treatment in congenital and acquired TTP have assisted in excellent pregnancy outcomes.


Thrombotic thrombocytopenic purpura, HELLP syndrome, Haemolytic uremic syndrome, Plasma exchange transfusion

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