Hepatoid carcinoma of ovary: a very rare histopathological finding

Authors

  • Nahida Hassan Wani Department of Gyne-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
  • Rupinder Sekhon Department of Gyne-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
  • Shevta Giri Department of Gyne-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
  • Sudhir K. Rawal Department of Uro-Gyne-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India

Keywords:

α-fetoprotein, CA125, Hepatoid carcinoma of ovary, Hepatocellular carcinoma, Immunohistochemistry

Abstract

Hepatoid carcinoma of the ovary is a rare histopathological variant that has phenotypic properties in common with hepato-cellular carcinoma and composed mainly of epitheloid cells. It presents with unilateral or bilateral ovarian masses with elevated serum α-feta-protein especially in post-menopausal female. We hereby discuss a very rare case of 58 years old female presented with abdominal pain and distension with high serum levels of CA 125 and AFP. She was diagnosed as hepatocellular carcinoma. CT guided FNAC of omentum revealed poorly differentiated carcinoma and on immuno-histochemical staining cells was positive for CK7, CK8/17 and AFP. The tumor cells were negative for CMA, PAX2/PAX8, CK20 and CK19. She was diagnosed with bilateral hepatoid carcinoma of ovary. This shows that histopathological examination and tissue immuno-histochemical staining plays an important role in distinguishing hepatoid variety of ovarian carcinoma from other ovarian tumors and hepatocellular carcinoma.

References

Ishikura H, Scully RE. Hepatoid carcinoma of the ovary: a newly described tumor. Cancer. 1987;60:2775-84.

Zizi-Sermpetzoglou A, Petrakopoulou N, Nikolaidou ME, Tepelenis N, Savvaidou V, Vasilakaki T. Hepatoid carcinoma of the ovary: a case report and review of the literature. Eur J Gynaecol Oncol. 2009;30:341-3.

Lazaro J, Rubio D, Repolles M, Capote L. Hepatoid carcinoma of the ovary and management. Acta Obstet Gynecol Scand. 2007;86:498-9.

Pandey M, Truica C. Hepatoid carcinoma of the ovary. J Clin Oncol. 2011;29(15):e446-8.

Tochigi N, Kishimoto T, Supriatna Y, Nagai Y, Nikaido T, Ishikura H. Hepatoid carcinoma of the ovary: a report of three cases admixed with a common surface epithelial carcinoma. Int J Gynecol Pathol. 2003;22:266-71.

Beurdeley M, Gauthier T, Piquet C, Fourcade L. Conservative treatment of big yolk sac tumor of the ovary in young girl. J Visc Surg. 2010;147:e265-7.

Yamamoto R, Ishikura H, Azuma M, Hareyama H, Makinoda S, Koyama Y, et al. Alpha-fetoprotein production by a hepatoid adenocarcinoma of the uterus. J Clin Pathol. 1996;49:420-2.

Downloads

Published

2017-01-04