Successful outcome in a patient with glioma of brain with twin pregnancy

Anjali Rani, Prashanta Krishna Gupta


We present a case of glioma in pregnant female with twin pregnancy. Gliomas during pregnancy are rare. Gliomas during pregnancy pose a risk to maternal and fetal life. The benefit-to-risk ratio should be carefully evaluated and discussed prior to get marriage and pregnancy. In present case, patient had non-specific symptom like seizure and no any focal neurological deficit, Caesarean Section (CS) was done at term with multidisciplinary group, including a neurosurgeon, obstetrician, anesthesiologist and neonatologist. She has been followed up to the present date and remains in good health.


Glioma of brain, Twin pregnancy

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Chang L, Looi-Lyons L, Bartosik L, Tindal S. Anesthesia for cesarean section in two patients with brain tumours. Can J Anesth. 1999;46:61-5.

Keles GE, Lamborn KR, Berger MS. Low-grade hemispheric gliomas in adults: a critical review of extent of resection as a factor influencing outcome. J Neurosurg. 2001;95:735-45.

Wilson CB, Bramwell V, Bonfill X, Cuzick J, Grant R, Guthrie D, et al. Central nervous system tumours. In: Williams CB, eds. Evidence-Based Oncology. London: BMJ Books; 2003: 561-564.

Wessels PH, Weber WEJ, Raven G, Ramaekers FCS, Hopman AHN, Twijnstra A. Supratentorial grade II astrocytoma: biological features and clinical course. Lancet Neurol. 2003;2:395-403.

Ellis TL, Stieber VW, Austin RC. Oligodendroglioma. Curr Treat Options Oncol. 2003;4:479-90.

Feigenberg SJ, Amdur RJ, Morris CG, Mendenhall WM, Marcus RB Jr, Friedman WA. Oligodendroglioma: does deferring treatment compromise outcome? Am J Clin Pathol. 2003;26:e60-6.

Lang FF, Olansen NE, DeMonte F, Gokaslan ZL, Holland EC, Kalhorn C, et al. Surgical resection of intrinsic insular tumors: complication avoidance. J Neurosurg. 2001;95:638-50.

Duffau H, Capelle L, Denvil D, Sichez N, Gatignol P, Lopes M, et al. Functional recovery after surgical resection of low grade gliomas in eloquent brain: hypothesis of brain compensation. J Neurol Neurosurg Psychiatry. 2003;74:901-7.

Peraud A, Meschede M, Eisner W, Ilmberger J, Reulen HJ. Surgical resection of grade II astrocytomas in the superior frontal gyrus. Neurosurgery. 2002;50:966-75.

Gonzalez-Aguero G, Gutierrez AA, Gonzalez-Espinosa D, Solano JD, Morales R, González-Arenas A, et al. Progesterone effects on cell growth of U373 and D54 human astrocytoma cell lines. Endocrine. 2007;32:129-35.

Fuglsang J, Ovesen P. Aspects of placental growth hormone physiology. Growth Horm IGF Res. 2006;16:67-85.

Jiang W, Xiang C, Cazacu S, Brodie C, Mikkelsen T. Insulin-like growth factor binding protein 7 mediates glioma cell growth and migration. Neoplasia. 2008;10:1335-42.

Schlenska-Lange A, Knupfer H, Lange TJ, Kiess W, Knüpfer M. Cell proliferation and migration in glioblastoma multiforme cell lines are influenced by insulin-like growth factor I in vitro. Anticancer Res. 2008;28:1055-60.

Bengtson NW, Linzer DI. Inhibition of tumor growth by the antiangiogenic placental hormone, proliferin-related protein. Mol Endocrinol. 2000;14:1934-43.

Rao BR. Pregnancy associated highly vascularized tumours negatively correlate with the levels of anti-angiogenic 17 alpha-hydroxyprogesterone Anticancer Res. 1997;17:1019-21.

Adini A, Kornaga T, Firoozbakht F, Benjamin LE. Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res. 2002;62:2749-52.

Ducray F, Colin P, Cartalat-Carel S, Pelissou-Guyotat I, Mahla K, Audra P, et al. Management of malignant gliomas diagnosed during pregnancy. Rev Neurol (Paris). 2006;162:322-9.

Goldschlager T, Steyn M, Loh V, Selvanathan S, Vonau M, Campbell S. Simultaneous craniotomy and caesarean section for trauma. J Trauma. 2009;66:E50-1.

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987-96.