A prospective study of predictors of metabolic syndrome in women with polycystic ovary syndrome

Authors

  • Jubie Gupta Department of Obstetrics and Gynaecology, Maharishi Markandeshwar Medical College and Hospital, Solan, Himachal Pradesh, India
  • Santosh Minhas Department of Obstetrics and Gynaecology, Maharishi Markandeshwar Medical College and Hospital, Solan, Himachal Pradesh, India
  • Monika Jindal Department of Obstetrics and Gynaecology, Maharishi Markandeshwar Medical College and Hospital, Solan, Himachal Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20220555

Keywords:

Metabolic syndrome, Obesity, Polycystic ovary syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is a well-known gynecological hormonal imbalance. The consequences of PCOS pose a substantial risk for the development of metabolic and cardiovascular abnormalities similar to those that make up metabolic syndrome (MBS). Therefore, there was a need to identify predictors for MBS in PCOS subjects and study their strength of association.

Methods: A prospective observational study was carried on 100 PCOS subjects for having features of MBS. MBS was diagnosed by National cholesterol education program’s adult treatment panel III 2001 criteria. Student’s independent t test, Chi square test and Fisher’s exact test were used for statistical analysis.

Results: The present study estimated the prevalence of MBS in women with PCOS to be 31%. MBS in PCOS was more prevalent in non-vegetarians (51.6%). The individual components of MBS criterion had a statistically significant p value (p=0.001 to 0.008) for development of PCOS. Raised levels of triglycerides, fasting blood sugars and fasting insulin tests were related directly to MBS development, with statistically significant p values (<0.001, <0.001 and 0.005), respectively.

Conclusions: Women with PCOS have a high prevalence of MBS and its individual components, particularly raised laboratory values of triglycerides, fasting blood sugars and fasting insulin. MBS in PCOS women is associated with advancing age and obesity.

References

Stein IF. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 1935;29(2):181-91.

Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005;352(12):1223-36.

Franks S. Polycystic ovary syndrome. N Engl J Med. 1995;333(13):853-61.

Rotterdam ESHRE/ASRM‐Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Human Reprod. 2004;19(1):41-7.

National Cholesterol Education Program (US). Expert panel on detection, treatment of high blood cholesterol in adults. Third report of the National cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). Circulation. 2002;106(25):3143-421.

Carmina E, Rosato F, Janni A, Rizzo M, Longo RA. Relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. Int J Clin Endocrinol Metab. 2006;91(1):2-6.

Dey R, Mukherjee S, Roybiswas R, Mukhopadhyay A, Biswas SC. Association of metabolic syndrome in polycystic ovarian syndrome: an observational study. J Obstet Gynaecol India. 2011;61(2):176-81.

Indu NR, Hiremath PB, Sanyal U, Hiremath R. Prevalence of metabolic syndrome in women with polycystic ovarian syndrome: an observational study in a tertiary care centre in Pondicherry, India. Int J Reprod Contracept Obstet Gynecol. 2018;7(9):3774-80.

Akshaya S, Bhattacharya R. Comparative study of clinical profile of lean and obese polycystic ovary syndrome women. Int J Fertil Steril. 2016;5(8):2530-4.

Ehrmann DA, Liljenquist DR, Kasza K, Azziz R, Legro RS, Ghazzi MN. PCOS/Troglitazone Study Group. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. Int J Clin Endocrinol Metab. 2006;91(1):48-53.

Mandrelle K, Kamath MS, Bondu DJ, Chandy A, Aleyamma TK, George K. Prevalence of metabolic syndrome in women with polycystic ovary syndrome attending an infertility clinic in a tertiary care hospital in south India. J Hum Reprod Sci. 2012;5(1):26.

Zahiri Z, Sharami SH, Milani F, Mohammadi F, Kazemnejad E, Ebrahimi H, et al. Metabolic syndrome in patients with polycystic ovary syndrome in Iran. Int J Fertil Steril. 2016;9(4):490.

Downloads

Published

2022-02-25

Issue

Section

Original Research Articles