Labor outcome among obese postdate women undergoing labor induction
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20220882Keywords:
Cesarean section, Delivery, Labor induction, Obesity, PostdateAbstract
Background: Maternal obesity and postdate pregnancy are common findings among pregnant women worldwide. We aimed to evaluate the influence of maternal obesity on the outcome of labor induction for postdate pregnant women.
Methods: We conducted a prospective observational study to compare 118 obese women (≥30 kg/m2) with 118 non-obese women (<30 kg/m2) undergoing labor induction for postdate pregnancy (≥41 weeks). We induced all participants by a uniform protocol according to the Bishop score. The primary outcome measures were the cesarean delivery (CD) rate and the rate of failed induction. Secondary outcomes included prolonged induction- delivery time, prolonged first and second stage of labor, and rate of instrumental delivery. We performed a multivariate regression model to assess for the relation between obesity and the study outcomes of interest.
Results: Cesarean delivery was significantly higher in obese women when compared with non-obese women (25.4% vs. 12.7%, p=0.02). Likewise, failed induction rate was significantly lower among non-obese women (5.1% vs. 14.4%. p=0.026). Obese women had increased odds for CD (adjusted odds ratio: 2.24; 95% confidence-interval: 1.13-4.33), failed induction rate (adjusted OR 2.96; 95% CI: 1.15-8.17), prolonged induction-delivery time (adjusted OR 4.57; 95% CI: 1.42-14.74), prolonged first stage of labor (adjusted OR 3.32; 95% CI: 1.07-9.89), prolonged second stage of labor (adjusted OR 4.21; 95% CI: 1.27-13.62), and rate of instrumental delivery (adjusted OR 2.97; 95% CI: 1.16-8.23).
Conclusions: Obesity adds more risk to postdate women undergoing induction of labor. Obesity increases the incidence of CD and failed induction among induced postdate women. Therefore, obstetricians should encourage obese women to reduce weight before getting pregnant, and to comply with the optimal weight gain during pregnancy in attempt to reduce the rates of postdating, CD and failed induction.
References
Ng M, Fleming T, Robinson M. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766-81.
Carlson NS, Hernandez TL, Hurt KJ. Parturition dysfunction in obesity: time to target the pathobiology. Reprod Biol Endocrinol. 2015;13:135.
Kobayashi N, Lim BH. Induction of labour and intrapartum care in obese women. Best Pract Res Clin Obstet Gynaecol. 2015; 29(3):394-405.
Goldstein RF, Abell SK, Ranasinha S. Association of gestational weight gain with maternal and infant outcomes: a systematic review and meta-analysis. JAMA. 2017;317(21):2207-25.
Arrowsmith S, Wray S, Quenby S. Maternal obesity and labour complications following induction of labour in prolonged pregnancy. BJOG. 2011;118(5):578-88.
Lee VR, Darney BG, Snowden JM. Term elective induction of labour and perinatal outcomes in obese women: retrospective cohort study. BJOG. 2016; 123(2):271-8.
Tanaka K, Matsushima M, Izawa T. Influence of maternal obesity on fetal growth at different periods of pregnancies with normal glucose tolerance. J Obstet Gynaecol Res. 2018;44(4):691-6.
Caughey AB, Stotland NE, Washington AE. Who is at risk for prolonged and postterm pregnancy? Am J Obstet Gynecol. 2009;200(6):683.e1-683-5.
Denison FC, Price J, Graham C. Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term. BJOG. 2008;115(6):720-5.
Dinatale A, Ermito S, Fonti I. Obesity and fetal-maternal outcomes. J Prenat Med. 2010;4(1):5-8.
Brusati V, Brembilla G, Cirillo F, et al. Efficacy of sublingual misoprostol for induction of labor at term and post term according to parity and membrane integrity: a prospective observational study. J Matern Fetal Neonatal Med. 2017;30(5):508-13.
Maged AM, El-Semary AM, Marie HM, et al. Effect of maternal obesity on labor induction in postdate pregnancy. Arch Gynecol Obstet. 2018;298(1):45-50.
Rasmussen OB, Rasmussen S. Cesarean section after induction of labor compared with expectant management: no added risk from gestational week 39. Acta Obstet Gynecol Scand. 2011;90(8):857-62.
Arrowsmith S, Kendrick A, Hanley JA. Myometrial physiology--time to translate? Exp Physiol. 2014; 99(3):495-502.
Carpenter JR. Intrapartum Management of the Obese Gravida. Clin Obstet Gynecol. 2016;59(1):172-9.
Wolfe KB, Rossi RA, Warshak CR. The effect of maternal obesity on the rate of failed induction of labor. Am J Obstet Gynecol. 2011;205(2):128.e1-7.
Cedergren MI. Non-elective caesarean delivery due to ineffective uterine contractility or due to obstructed labour in relation to maternal body mass index. Eur J Obstet Gynecol Reprod Biol. 2009;145(2):163-6.
Fyfe EM, Rivers KS, Thompson JM. Elevated maternal lipids in early pregnancy are not associated with risk of intrapartum caesarean in overweight and obese nulliparous women. BMC Pregnancy Childbirth. 2013;13:143.
Moynihan AT, Hehir MP, Glavey SV. Inhibitory effect of leptin on human uterine contractility in vitro. Am J Obstet Gynecol. 2006;195(2):504-9.
Zhang J, Bricker L, Wray S. Poor uterine contractility in obese women. BJOG. 2007;114(3):343-8.
Mercer BM, Macpherson CA, Goldenberg RL. Are women with recurrent spontaneous preterm births different from those without such history? Am J Obstet Gynecol. 2006;194(4):1176-85.
Mission JF, Marshall NE, Caughey AB. Obesity in pregnancy: a big problem and getting bigger. Obstet Gynecol Surv. 2013;68(5): 389-99.
Ronzoni S, Rosen H, Melamed N. Maternal obesity class as a predictor of induction failure: a practical risk assessment tool. Am J Perinatol. 2015; 32(14):1298-304.
Lassiter JR, Holliday N, Lewis DF. Induction of labor with an unfavorable cervix: how does BMI affect success? J Matern Fetal Neonatal Med. 2016;29(18): 3000-2.
Kominiarek MA, Zhang J, Vanveldhuisen P, et al. Contemporary labor patterns: the impact of maternal body mass index. Am J Obstet Gynecol. 2011;205(3): 244.e1-8.
Roloff K, Peng S, Sanchez-Ramos L. Cumulative oxytocin dose during induction of labor according tomaternal bodymass index. Int J Gynaecol Obstet. 2015;131(1):54-8.
Beckwith L, Magner K, Kritzer S. Prostaglandin versus mechanical dilation and the effect of maternal obesity on failure to achieve active labor: a cohort study. J Matern Fetal Neonatal Med. 2017;30(13):1621-6.