DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20220879

Associated factors for maternal-foetal complications in pregnant women with sickle cell disease at the departmental University Hospital of Borgou and Alibori (Benin)

Mahublo V. Vodouhe, Awade A. Obossou, Falilatou A. Mohamed, Fanny M. H. Ahouingnan, Justin Y. Chogou, Raoul Atade, Rachidi S. Imorou, Joseph Agossou

Abstract


Background: Sickle cell disease is one of the most common genetic disorders in the world, with a high prevalence in Africa. It is a pathology that threatens the maternal-fetal prognosis in case of pregnancy. The objective of this study was to describe the maternal-foetal complications and to identify the factors associated with maternal-foetal complications in sickle cell pregnant women (SP).

Methods: This was a descriptive cross-sectional study with retrospective data collection over a period of 4 years (01 January 2015 to 31 August 2019). The study population was All SP who had given birth in the maternity ward of the UH of Borgou/Alibori.

Results: We recorded 130 SP out of 10087 admissions, either a frequency of 1.3%. There were 119/130 exploitable files. Maternal complications during pregnancy were: vaso-occlusive crises 79%; severe anaemia 27.7%; hyponatremia 10.1%; vasculo-renal syndromes 18.4%; infections 74.8%. The foetal complications during pregnancy were: Preterm births 38.6%, in utero deaths 17.6%, low birth weight 54.7%. Early neonatal mortality was 8.4% (8/95). There was a 4.2% (5/119) of maternal deaths. Low educational level of the SP, SS genotype, insufficient antenatal follow-up and antenatal follow-up outside the specialized center for the care of sickle cell pregnant women (SCCSP) were the factors associated with maternal-foetal complications in the SP.

Conclusions: The association of pregnancy and sickle cell disease is frequent in West Africa, particularly in Benin, and is characterised by numerous maternal-foetal complications that are associated with certain factors.


Keywords


Sickle cell disease, Pregnancy, Vaso-occlusive crises

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References


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