DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20220887

Improvement of semen quality after treatment with folic acid and zinc in subfertile men in a tertiary hospital

Nurjahan Begum, Shaheen Ara Anwary, M. Alfazzaman, Munshi Akid Mostofa, Zeenat Mahzabin, M. M. Mafizur Rahman, Mahbuba Akter, Kazi Sohel Iqbal, Rehena Akhter

Abstract


Background: The 50% of all male infertility is idiopathic, and there is currently no recognized treatment. The effectiveness of a nonprescription nutraceutical comprising eight nutrients on sperm quality in males with idiopathic infertility was studied. The aim of the study was to evaluate improvement of semen quality after treatment with folic acid and zinc in subfertile men.

Methods: This prospective observational study was carried out in the infertility unit, department of obstetrics and gynaecology, Bangabandhu Sheikh Mujib medical university (BSMMU), Dhaka, Bangladesh from January 2018 to June 2020. Approval from local ethics committee was obtained for this study.

Results: One hundred and twenty-five male subfertile patients were included in this study. Most men, 99 (79.2%) belong to more than 30 years, followed by 26 (20.8%) less than 30 years, range was 25 to 50 years. Mean ± SD age was 35.3±5.1 years. Rapid linear (RL) before treatment were 16.06±14.46 (mean ± SD) and after treatment were 22.82±13.40 (mean ± SD). Slow linear (SL) before treatment were 17.56±12.06 (mean ± SD) and after treatment were 19.75±9.25 (mean ± SD). Non progressive (NP) before treatment were 10.82±8.95 (mean ± SD) and after treatment were 10.12±7.34 (mean ± SD). Morphology of the sperm before treatment were 19.43±15.48 (mean ± SD) and after treatment were 30.18±19.12 (mean ± SD).

Conclusions:  Our research findings fully correspond to the above research results, so it can be said that treatment of subfertile men with micronutrients like folic acid and zinc sulfate causes increase of semen quality and thus plays a key role in treatment of male subfertility.


Keywords


Male subfertility, Semen analysis, Sperm quality

Full Text:

PDF

References


Gurunath S, Pandian Z, Anderson RA, Bhattacharya S. Defining infertility-a systematic review of prevalence studies. Human Reproduct Update. 2011;17(5):575-88.

Westroem L. Incidence, prevalence, and trends of acute pelvic inflammatory disease and its consequences in industrialized countries. Am J Obstetr Gynecol. 1980;138(7):880-92.

Wallach EE, Jaffe SB, Jewelewicz R. The basic infertility investigation. Fertility Sterility. 1991;56(4):599-613.

Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reproduct Biol Endocrinol. 2015;13(1):1-9.

Tamrakar SR, Bastakoti R. Determinants of infertility in couples. J Nepal Health Res Council. 2019;17(1):85-9.

Vasan SS. Semen analysis and sperm function tests: How much to test? Indian J Urol. 2011;27(1):41.

Krausz C. Male infertility: pathogenesis and clinical diagnosis. Best Pract Res Clin Endocrinol Metab. 2011;25(2):271-85.

Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette Jr LJ et al. Male reproductive health and environmental xenoestrogens. Env Health Persp. 1996;104(4):741-803.

Menchini-Fabris GF, Canale D, Izzo PL, Olivieri L, Bartelloni M. Free L-carnitine in human semen: its variability in different andrologic pathologies. Fertil Steril. 1984;42:263e7.

Dixon-Mueller R. The sexuality connection in reproductive health. Studies Family Planning. 1993:269-82.

Zhang H, Zheng RL. Possible role of nitric oxide on fertile and asthenozoospermic infertile human sperm functions. Free Rad Res. 1996;25:347e54.

Suleiman SA, Ali ME, Zaki ZM, El-Malik EM, Nasr MA. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl. 1996;17:530e7.

Kessopoulou E, Powers HJ, Sharma KK, Pearson MJ, Russell JM, Cooke ID et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995;64:825e31.

Vezina D, Mauffette F, Roberts KD, Bleau G. Selenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution. Biol Trace Elem Res. 1996;53:65e83.

Keskes-Ammar L, Feki-Chakroun N, Rebai T, Sahnoun Z, Ghozzi H, Hammami S et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl. 2003;49:83e94.

Wong WY, Hans MWMM, Chris MGT, Roelof M, Gerhard AZ, Régine PMS. Effects of Folic Acid and Zinc Sulfate on Male Factor Subfertility; a double-blind, randomized, placebo-controlled trial. Fertil Steril male factor. 2002;77(3):491-8.