Impact of obesity on semen quality in men of infertile couples: a cross-sectional study in a tertiary care centre
Keywords:Male infertility, Obesity, BMI, Waist circumference, Waist-hip ratio, Semen quality
Background: Obesity is an emerging problem worldwide. The aim of the study was to determine the association of Body mass index and central obesity with semen parameters in men of infertile couples.
Methods: This was a descriptive study conducted in a population that included 219 men of infertile couples who attended the infertility clinic. A detailed history was taken from the participants and measurements of height, weight, waist circumference and hip circumference were done by standard methods. General, systemic and urogenital tract examinations were done. The participants were advised to collect semen specimens and semen was analyzed and various semen parameters were noted based on WHO criteria 2010.
Results: Among the overweight and obese men, 12.7% and 20.5% were oligozoospermic respectively. Asthenozoospermia was seen in 21.2% and 25% of overweight and obese men. Among men with waist circumference ≥102 cm, 14.3% had oligozoospermia and 35.7% of men had asthenozoospermia. Around 12.2% of men with a Waist-hip ratio >0.9 had oligozoospermia and 19.8% of them had asthenozoospermia.
Conclusions: A significant negative association was seen between WHR and sperm concentration, total sperm count, total progressive motility and total motility were seen to be removed. There was no significant association between WC, BMI and sperm concentration, total sperm count, total progressive motility, and total motility.
Hochschild F, Adamson GD, Mouzon J, Ishihara O, Mansour R, Nygren K, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009;92(5):1520-4.
Practice Committee of American Society for Reproductive Medicine. Diagnostic evaluation of the infertile male: a committee opinion. Fertil Steril. 2012;98(2):294-301.
Jensen TK, Andersson AM, Jørgensen N, Andersen AG, Carlsen E, Petersen JH, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004;82(4):863-70.
WHO. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies, 2021. Available from: www.who.int/nutrition/publications/bmi_asia_strategies. Accessed on 23 February 2022.
WHO. Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation, 2021. Available at: https://www.who.int/publications/i/item/9789241501491. Accessed on 23 February 2022.
Jensen TK, Andersson AM, Jørgensen N, Andersen AG, Carlsen E, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004;82(4):863-70.
Webber L, Divajeva D, Marsh T, McPherson K, Brown M, Galea G, et al. The future burden of obesity-related diseases in the 53 WHO European-Region countries and the impact of effective interventions: a modelling study. BMJ Open. 2014;4(7):004787.
Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, Sørensen TI, Olsen J. Subfecundity in overweight and obese couples. Hum Reprod. 2007;22(6):1634-7.
Kirchengast S, Huber J. Body composition characteristics and fat distribution patterns in young infertile women. Fertil Steril. 2004;81(3):539-44.
Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, Lee PA. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril. 2008;90(2):346-51.
Stewart TM, Liu DY, Garrett C, Jørgensen N, Brown EH, Baker HW. Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm output. Hum Reprod. 2009;24(7):1561-8.
Nguyen RH, Wilcox AJ, Skjaerven R, Baird DD. Men's body mass index and infertility. Hum Reprod. 2007;22(9):2488-93.
Eisenberg ML, Kim S, Chen Z, Sundaram R, Schisterman EF, Buck Louis GM. The relationship between male BMI and waist circumference on semen quality: data from the LIFE study. Hum Reprod. 2014;29(2):193-200.
Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertil Steril. 2008;90(6):2222-5.
Martini AC, Tissera A, Estofán D, Molina RI, Mangeaud A, et al. Overweight and seminal quality: a study of 794 patients. Fertil Steril. 2010;94(5):1739-43.
Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010;93(7):2222-31.
Duits FH, Wely M, Veen F, Gianotten J. Healthy overweight male partners of subfertile couples should not worry about their semen quality. Fertil Steril. 2010;94(4):1356-9.
Nicopoulou SC, Alexiou M, Michalakis K, Ilias I, Venaki E, Koukkou E, et al. Body mass index vis-à-vis total sperm count in attendees of a single andrology clinic. Fertil Steril. 2009;92(3):1016-7.
MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010;16(3):293-311.
Hammiche F, Laven JS, Twigt JM, Boellaard WP, Steegers EA, Theunissen RP. Body mass index and central adiposity are associated with sperm quality in men of subfertile couples. Hum Reprod. 2012;27(8):2365-72.
Fejes I, Koloszár S, Szöllosi J, Závaczki Z, Pál A. Is semen quality affected by male body fat distribution? Andrologia. 2005;37(5):155-9.