Efficacy of Amla (Emblica officinanis) and Shibe yamani (potash alum) in the management of Candida vaginitis: a randomized standard controlled trial
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20161333Keywords:
Candida vaginitis, Amla, Shibe yamani, Fluconazole, Vulvovaginal pruritusAbstract
Background: It has been estimated that 75% of all females experience at least one episode of Candida vaginitis with approximately 40-50% reporting a recurrence during their lifetime. The symptoms of vulvovaginal candidiasis are often painful and uncomfortable to the patient. The objective of this study was to assess the efficacy of Amla and Shibe yamani in the management of Candida vaginitis.
Methods: This randomized, single blind, standard controlled study was done to compare the efficacy of Amla and Shibe yamani against fluconazole and 2% miconazole on diagnosed subjects of Candida vaginitis. Test group (n=30) received Amla with honey orally and Shibe yamani intra-vaginally at bed time for 3 wks. Whereas control group received standard regime of single dose fluconazole 150 mg orally and 5g of miconazole 2% cream intravaginally for 7 days. The primary outcome measure was relief in the vulvovaginal pruritus (reduction in 5D itch score). Secondary outcome measures included change in wet mount and improvement in vaginal discharge.
Results: Vulvovaginal pruritus significantly decreased (P<0.001) after intervention in the two groups. Marked improvement was observed in vaginal discharge (P<0.001) in both the groups.70% of patients in test group and 80% in control group showed change in wet mount.
Conclusions: Test drugs provide statistically significant improvement in vulvovaginal pruritus, vaginal discharge and in wet mount test without any apparent side effects. It can serve as an alternative treatment for Candida vaginitis.
References
Heng LZ, Chen Y, Tan TC. Treatment of recurrent vulvo-vaginal candidiasis with sustained-release butoconazole pessary. Singapore med J. 2012;53(12):e269-71.
Lauren B, Lambert LC, Soper DE. Vaginitis: making sense of over-the-counter treatment options. Infectious disease in obstetrics and gynaecology. 2007;1-4.
Achkar JM, Fries BC. Candida infections of the genitourinary tract. Clinical microbiology reviews. 2010;23(2):253-73.
Dota KFD, Consolaro MEL, Svidzinski TIE, Bruschi ML. Antifungal activity of Brazilian propolis microparticles against yeasts isolated from vulvovaginal candidiasis. Evidenced-based complementary and alternative medicine. 2011;1-8.
Nwadioha SI, Egah DZ, Alao OO, Iheanacho E. Risk factors for vaginal candidiasis among women attending primary health care centres of Jos, Nigeria. Journal of clinical medicine and research. 2010;2(7):110-3.
Ogunshe AAO, Omotoso MA, Bello VB. The in vitro antimicrobial activities of metabolites from Lactobacillus strains on Candida species implicated in Candida vaginitis. Malaysian J Med Sci. 2011;18(4):13-25.
Hakeem MA. Bustanul Mufradat. New Delhi: Idarae Kitabul Shifa; 2002. pp. 90-91, 176-177.
Baitar I. AlJami al Mufradat al Advia wa Alaghzia (Urdu Translation). Vol I. New Delhi: CCRUM; 2000. pp. 129-131.
Najmul Ghani. Khazianul Advia. Lucknow: Munshi Naval Kishore Press; YNM. pp. 187-189,482-485.
Ayub M. Tarjumah Aqsarai sharah mojaz (urdu translation ). vol I. Lucknow: Munshi Naval Kishore Press; YNM. pp. 693-694.
Ibrahim al Maghrabi AS. Kitab al- Fatah fi al tadawi (Urdu translation). 1st ed. New Delhi: Govt. of India Ministry of Health & Family Welfare Dept. of Ayush; 2007. pp. 107,212-213.
Kabeeruddin. Makhzanul Mufradat. New Delhi: Idara Kitabul Shifa; 2007. pp. 49- 50,141-142.
Sina I. Al Qanoon Fit Tib (Urdu trans. by Kantoori GH). New Delhi: Idarae Kitabul Shifa; YNM. pp. 454, 1065, 1095.
Nath A, Raghunatha P, Joshi SR. Diversity and Biological Activities of Endophytic Fungi of Emblica officinalis, an Ethnomedicinal Plant of India. The Korean Society of Mycology. 2012;40(1):8-13.
Arora A, Kumar I, Sen R, Singh J. Emblica officinalis (Amla): Physico-Chemical and Fatty Acid Analysis from Arid Zone of Rajasthan. International journal of basic and applied medical sciences. 2011;1(1):89-92.
Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. New Delhi: Springer India (P) Ltd; 2007. p. 238-239.
Flayeh RAA. Antifungal activity of some plant extract and alum on yeast isolated from mouth lesions. Euphrates journal of agriculture science. 2010;2(2):1-4.
Rupesh S, Winnier JJ, Nayak UA, Rao AP, Reddy NV. Comparative evaluation of the effects of an alum- containing mouth rinse and a saturated saline rinse on the salivary levels of streptococcus mutans. Journal of Indian society of pedodontics and preventive dentistry. 2010;3(8):138-44.
Altaei TS, Jubouri RHA. Evaluation of the efficacy of alum suspension in treatment of recurrent ulcerative ulceration. J College Dentistry. 2005;17(2):45-8.
Nadkarni KM. Indian Plants and Drugs. New Delhi: Srishti Book Distributors; 2005. pp. 31, 151-152.
Faraji R, Rahimi MA, Assarehzadegan M. Prevalence of Vaginal Candidiasis infection in women referred to Kermanshah hygienic centres Iran in 2010. Life Science Journal. 2012;9(4):1280-3.
Qarshi MH. Jame ul Hikmat. New Delhi: Idarae Kitabul Shifa; 2011. pp. 1121-1123.
Monjaraz S, Peggy EA, Victor MV, Beatriz X, Yolandadel CP. A molecular epidemiological study of prevalence of Candida spp. in women in the city of Tuxtla Gutierrez, Chiapas. International biotechnology color journal. 2012;2(2):6-14.
Saeed S, Tariq P. Antimicrobial activities of Emblica officinalis and Coriandrum sativum against Gram Positive bacteria and Candida albicans. Pak J Bot. 2007;39(3):913-7.
Nafis I, Nafisi K. Urdu translation by Kabeeruddin. New Delhi: Ejaz Publication; 1934. p. 277-278.
