DOI: https://dx.doi.org/10.18203/2320-1770.ijrcog20221019
Published: 2022-04-27

Analysis of successful outcome in patients undergoing homologous intrauterine insemination

Kavitha Marimuthu, Padmalatha Dakshnamurthy, Udhayarani Kailash

Abstract


Background: Intrauterine insemination (IUI) is a cost-effective, non-invasive and its success depends on the various factors. The factors associated with the success of IUI and its literature is least available in the Indian context. Objectives were to analyze the outcome of patients undergoing homologous IUI in terms of pregnancy rates (clinical pregnancy) and its predictors for the outcomes.

Methods: This is a prospective observational study among 200 couples with infertility undergoing therapeutic homologous IUI in a tertiary care centre. Among the study participants, undergoing IUI, after obtaining the informed written consent, the data related to the outcomes and associated factors were collected through a pre structured Questionnaire.

Results: Among the study participants who undergone the procedure, 40 (20%) become positive for pregnancy. Of the 40 positive, 30 (15%) delivered normal babies and 7 (14%) went for spontaneous abortions and 1 (0.5%) went for D and C. Type of infertility, drug for induction of ovulation, age in years, years of marriage, day of ovulation, no. of ovulation induction and were not statistically significant with the outcomes. Endometrial thickness, greatest dimension of follicular size, increased total sperm count, percentage of motility, post wash count and post wash motility were significantly associated with the positive outcomes.

Conclusions: Since the success rate of the IUI is comparable to the other studies reported, and the procedure is relatively cheaper, the same can be recommended as the simple and cost effective first line management of certain specific indications of the infertility.


Keywords


IUI, Infertility, Successful outcome in IUI

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References


Mayo Clinic. Intrauterine insemination (IUI)-Mayo Clinic. 2015. Available from: https://www.mayoclinic.org/tests-procedures/intrauterine-insemination/about/pac-20384722. Accessed on Dec, 3, 2020.

Ombelet W, Deblaere K, Bosmans E, Cox A, Jacobs P, Janssen M et al. Semen quality and intrauterine insemination. Reprod Biomed Online. 2003;7(4):485-92.

Allahbadia GN. Intrauterine Insemination: Fundamentals Revisited. J Obstet Gynaecol India. 2017;67(6):385-92.

COHEN MR. Intrauterine insemination. Int J Fertil. 1962;7:235-40.

Group TECW. Intrauterine insemination. Hum Reprod Update. 2009 May 1;15(3):265–77.

Fanchin R, Olivennes F, Righini C, Hazout A, Schwab B, Frydman R. A new system for fallopian tube sperm perfusion leads to pregnancy rates twice as high as standard intrauterine insemination. Fertil Steril. 1995;64(3):505-10.

Karlström PO, Bergh T, Lundkvist O. A prospective randomized trial of artificial insemination versus intercourse in cycles stimulated with human menopausal gonadotropin or clomiphene citrate. Fertil Steril. 1993;59(3):554-9.

Cohlen BJ, Velde ER, van Kooij RJ, Looman CW, Habbema JD. Controlled ovarian hyperstimulation and intrauterine insemination for treating male subfertility: a controlled study. Hum Reprod. 1998;13(6):1553-8.

Brzechffa PR, Daneshmand S, Buyalos RP. Sequential clomiphene citrate and human menopausal gonadotrophin with intrauterine insemination: the effect of patient age on clinical outcome. Hum Reprod. 1998;13(8):2110-4.

Peterson CM, Hatasaka HH, Jones KP, Poulson AMJ, Carrell DT, Urry RL. Ovulation induction with gonadotropins and intrauterine insemination compared with in vitro fertilization and no therapy: a prospective, nonrandomized, cohort study and meta-analysis. Fertil Steril. 1994;62(3):535-44.

Dodson WC, Haney AF. Controlled ovarian hyperstimulation and intrauterine insemination for treatment of infertility. Fertil Steril. 1991;55(3):457-67.

Sunde A, Kahn JA, Molne K. Intrauterine insemination: a European collaborative report. Hum Reprod. 1988;3(2):69-73.

Jayakrishnan K, Abraham S, Nambiar D. Factors affecting success of intrauterine insemination: a 3-year prospective study. Int J Reprod Contraception, Obstet Gynecol. 2016;1:1077-83.

Hirsch AM, Hirsch SM. The Effect of Infertility on Marriage and Self. J Obstet Gynecol Neonatal Nurs. 1989;18(1):13-20.

Valsangkar S, Bodhare T, Bele S, Sai S. An evaluation of the effect of infertility on marital, sexual satisfaction indices and health-related quality of life in women. J Hum Reprod Sci. 2011;4(2):80-5.

Ahmed B, Vaidyanathan G, Arumughan Pillai S, AlSabti J, Khaduri M Al, Pathare A. Factors Influencing the Success Rate of Intrauterine Insemination: A Retrospective Study in Sultan Qaboos University Hospital. J Women’s Heal Care. 2017;5-6.

Cantineau AEP, Cohlen BJ, Heineman MJ. Ovarian stimulation protocols (anti-oestrogens, gonadotrophins with and without GnRH agonists/antagonists) for intrauterine insemination (IUI) in women with subfertility. Cochrane Database Syst Rev. 2007;(2):CD005356..

Panda B, Mohapatra L, Sahu MC, Padhy RN. Success in pregnancy through intrauterine insemination at first cycle in 300 infertile couples: an analysis. J Obstet Gynaecol India. 2014;64(2):134-42.