DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20221691

Yolk sac tumor, a rare and challenging ovarian malignancy: case report

Anjum Ara, Kanika Kumari, Sushma Rani, Indu Chawla, Arvind Ahuja, Ravi H. Phulware

Abstract


Yolk sac tumors (YST) are rare and rapidly developing neoplasm presenting in young females. They are second most common germ cell tumor after dysgerminomas. Fertility preservation is an important concern in treatment of patients of YST. We present a case of 22 years nulliparous female with rapidly evolving abdominal mass. The patient underwent fertility preserving surgery with four cycles of post operative bleomycin etoposide and paclitaxel (BEP) chemotherapy and is fairly doing well. BEP chemotherapy has successfully improved the treatment outcomes of YST patients.


Keywords


Yolk sac tumor, Germ cell tumor, Fertility preservation, BEP

Full Text:

PDF

References


Rudaitis V, Mickys U, KatinaitÄ— J, Dulko J. Successful treatment of advanced stage yolk sac tumour of extragonadal origin: a case report and review of literature. Acta Med Litu. 2016;23(2):110-6.

Royal College of Obstetricians and Gynocologists. Management of Female Malignant Ovarian Germ Cell Tumours. Scientific Impact Paper No. 52. 2016. Available at: https://www.rcog.org.uk/globalassets/ documents/guidelines/scientific-impact-papers/sip_52.pdf. Accessed on 16 January 2022.

Dunn TN, Khazaeian K, Coffey DM, Rohozinski J, Kovanci E, Edwards CL, Tung CS. Successful yolk-sac tumor treatment with fertility-sparing partial oophorectomy. Gynecol Oncol Rep. 2018;27:22-4.

NCCN clinical Practice Guidelines in Oncology, Ovarian Cancer including Fallopian Tube Cancer and Primary peritoneal Cancer. 2017. Available at: https://www2.tri-kobe.org/nccn/guideline/gynecolo gical/english/ovarian. Accessed on 16 January 2022.

Rouge T, Pautier P, Duvillard P, Rey A, Morice P, Haie-Meder C, et al. Survival and reproductive outcomes of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor. Ann Oncol. 2008;19(8):1435-41.