DOI: https://dx.doi.org/10.18203/2320-1770.ijrcog20222300
Published: 2022-08-29

A study on effect of vitamin d supplementation in vitamin D deficient females with polycystic ovarian syndrome

Sakshi Garg, Nishi Makhija

Abstract


Background: Polycystic ovarian syndrome is one of the most common metabolic and endocrine disorders among women, whereas vitamin D is a steroid with hormone like activity and also considered as a missing link between insulin resistance and PCOS due to its underlying mechanism of action in reducing insulin resistance thereby altering pathogenesis behind PCOS symptoms.

Methods: A prospective cohort comparative observational study was carried out from July 2019 to December 2020 in 96 vitamin D deficient females with PCOS (polycystic ovarian-syndrome). All females were randomly recruited under group A and B with equal proportion of 1:1, where group A were given metformin (500 mg twice daily) only and group B were given metformin (500 mg twice daily) plus vitamin D 60000 IU weekly for 24 weeks. Baseline clinical, hormonal, metabolic, sonographic parameters were compared before and after treatment.

Results: Significant improvement was seen in various parameters in both the groups, like oligomenorrhoea improved in 41.67% individuals. FG score improved from mean of 10.28±2.02 in group B to 8.44±2.23 with p<0.0001. Acne improved in both groups equally in 22.92%. Polycystic ovary pattern improved in 14.58% individuals of group B with p<0.0001. Serum total testosterone improved in 16.71% in group A and in 22.92% in group B. HOMA-IR was also reduced in both groups effectively and was statistically significant with p=0.017 in group A and p=0.001 in group B.

Conclusions: Remarkable improvement was seen in clinical, hormonal, metabolic and sonographic parameters in group B and noteworthy reduction in HOMA-IR, BP and triglyceride values was also seen. Hence, supplementation of vitamin D is highly effective in improving PCOS and preventing future consequences as well.


Keywords


PCOS, Polycystic ovarian syndrome, Vitamin D deficiency

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References


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