DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20221658

Association of antithrombin (antithrombin III) gene mutation with unexplained recurrent pregnancy loss

Ferdous A. Banu, Masuda Sultana, Surayea Bulbul, Sanjukta Chowdhury, Khadiza Begum, Shahidul Islam, Nahreen Akhtar

Abstract


Background: Recurrent pregnancy loss (RPL) is an emotionally painful occurrence for couples and presents Obstetricians with a difficult clinical problem. Because a primary etiology cannot be determined in roughly half of the instances, it is irritating for both patients and obstetricians. The present study aimed to determine the association of the antithrombin III gene (SERPINC1) mutation with unexplained RPL.

Methods: This case-control observational study was conducted at the out-patient department of feto-maternal medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, with a total sample size of was 68, with 34 in the control group and 34 in the case/RPL group.

Results: The mean±standard deviation (SD) age of the RPL group was 28.44±5.25, and in the control group it was 29.15±4.72. The mean±SD body mass index (BMI) was 24.95±3.48 and 23.69±4.07 in RPL and control groups respectively. Among the RPL group patients, 68% (23) had the primary RPL, and 32% (11) had a second pregnancy loss.

Conclusions: 5.88% of the cases have a heterozygous mutation which might be the cause of their RPL. There was no homozygous mutation was found for G878A in the case group. The allele for G878A was also higher in the case group. But these differences were statistically non-significant. So, to clarify this association with unexplained RPL, further research is necessary including multi-centre and large sample sizes.


Keywords


Mutation, Pregnancy, Recurrent, Antithrombin

Full Text:

PDF

References


Compte A, Brunel N, Goldman-Rakic PS, Wang XJ. Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. Cerebral Cortex. 2000;10(9):910-23.

Chan YY, Jayaprakasan K, Zamora J, Thornton JG, Raine-Fenning N, Coomarasamy A. The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. Human Reprod Update. 2011;17(6):761-71.

Stirrat GM. The recurrent miscarriage I: definition and epidemiology. The Lancet. 1990;336(8716):673-5.

Brenner B, Mandel H, Lanir N, Younis J, Rothbart H, Ohel G, Blumenfeld Z. Activated protein C resistance can be associated with recurrent fetal loss. Br J Haematol. 1997;97(3):551-4.

Ross R, Rissanen J, Pedwell H, Clifford J, Shragge P. Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men. J Appl Physiol. 1996;81(6):2445-55.

Carrington PJ, Scott J, Wasserman S. Models and methods in social network analysis. Cambridge University Press. 2005.

Creagh SC, Littlejohn RG. Semiclassical trace formulas in the presence of continuous symmetries. Physical Review A. 1991;44(2):836.

Warburton D, Fraser FC. Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit. Am J Human Genet. 1964;16(1):1.

Brown PF, Della Pietra SA, Della Pietra VJ, Mercer RL. Word-sense disambiguation using statistical methods. In 29th Annual meeting of the Association for Computational Linguistics. 1991;264-70.

Ihmels J, Friedlander G, Bergmann S, Sarig O, Ziv Y, Barkai N. Revealing modular organization in the yeast transcriptional network. Nature Genetics. 2002;31(4):370-7.

O'Corry‐Crowe GM, Suydam RS, Rosenberg A, Frost KJ, Dizon AE. Phylogeography, population structure and dispersal patterns of the beluga whale Delphinapterus leucas in the western Nearctic revealed by mitochondrial DNA. Mol Ecol. 1997;6(10):955-70.

Alfirevic Z, Roberts D, Martlew V. How strong is the association between maternal thrombophilia and adverse pregnancy outcome?: A systematic review. Eur J Obstet Gynecol Reprod Biol. 2002;101(1):6-14.

Taher BJ, Farid MM. Cyclic microwave thawing of frozen meat: experimental and theoretical investigation. Chemical Engineering and Processing: Process Intensification. 2001;40(4):379-89.

Castanias GA, Rosenberg LD, Fried MS, Geremia TR. Survey of the Federal Circuit's Patent Law Decisions in 2006: A New Chapter in the Ongoing Dialogue with the Supreme Court. Am UL Rev. 2006;56:793.

Zebda A, Cosnier S, Alcaraz JP, Holzinger M, Le Goff A, Gondran C, Boucher F, Giroud F, Gorgy K, Lamraoui H, Cinquin P. Single glucose biofuel cells implanted in rats power electronic devices. Scientific reports. 2013;3(1):1-5.

Fathollahi-Fard AM, Govindan K, Hajiaghaei-Keshteli M, Ahmadi A. A green home health care supply chain: New modified simulated annealing algorithms. J Cleaner Prod. 2019;240:118200.

Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, et al. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host Microbe. 2020;27(3):325-8.

Alaylar B, Aygün B, Turhan K, Karadayi G, Şakar E, Singh VP, et al. Characterization of gamma-ray and neutron radiation absorption properties of synthesized quinoline derivatives and their genotoxic potential. Rad Physics Chem. 2021;184:109471.

Bernardi L, Wdowczyk-Szulc J, Valenti C, Castoldi S, Passino C, Spadacini G, Sleight P. Effects of controlled breathing, mental activity and mental stress with or without verbalization on heart rate variability. J Am Coll Cardiol. 2000;35(6):1462-9.

Ozturkmenoglu O, Ceylan NM, Alpkocak A. DEMIR at ImageCLEFMed 2013: The Effects of Modality Classification to Information Retrieval. CLEF (Working Notes). 2013;1179.

Chakraborty N, Ghosh R, Ghosh S, Narula K, Tayal R, Datta A, Chakraborty S. Reduction of oxalate levels in tomato fruit and consequent metabolic remodelling following overexpression of a fungal oxalate decarboxylase. Plant Physiol. 2013;162(1):364-78.

Pedaste M, Mäeots M, Siiman LA, De Jong T, Van Riesen SA, Kamp ET, et al. Phases of inquiry-based learning: Definitions and the inquiry cycle. Educ Res Rev. 2015;14:47-61.