Comparative analysis of single versus double intrauterine insemination

Pratima T. Wagh


Background: IUI is simple, less costly compared to other reproductive techniques but there is discrepancy even in recent studies about the timing of IUI. Compared with single IUI, a second consecutive IUI adds significantly to cost and psychological burden, making it important to confirm its beneficial effects before recommending this procedure on large scale.

Methods: It is hospital based retrospective study, carried out in a private tertiary care hospital of Mumbai over a period of one year. All cases who had already undergone IUI during the given time frame were consecutively selected as per inclusion & exclusion criteria for the study. We considered different factors in the study group and their effect on the fertility of the couples.

Results: Out of 150 couples, 119 (79.3%) underwent single IUI during the study and 31 (20.7%) underwent double IUI. 72.67% couple had infertility for 1-3 years, 90.67% primary and 9.33% secondary infertility, 51.3% women with normal BMI and 77.8% with PCOS, 29.4% of single IUI and 32.3% of double IUI group had positive pregnancies.  As only the couples with normal semen analysis were selected, male factors like age and co-morbidities in the male did not show any significant effect on the fertility in the study groups.

Conclusions: Women with younger age, normal BMI and with PCOS have better chances of pregnancy in first 3 attempts of IUI with controlled ovarian stimulation and there is no difference in the pregnancy rates by using either double IUI or single IUI in the treatment of sub fertile couple.


HCG, Infertility, Intrauterine insemination

Full Text: