DOI: https://dx.doi.org/10.18203/2320-1770.ijrcog20222080
Published: 2022-08-29

Relationship between vitamin D3 deficiency and polycystic ovarian syndrome

Esraa B. Elsadany, Shereef L. Elshwaikh, Hesham M. Borg, Nagwa M. Alghorab

Abstract


Background: Vitamin D3 (VD3), a seco-steroid that is synthesized in skin and sequentially metabolized in liver and kidneys in humans, has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. Polycystic ovary syndrome (PCOS) is a common cause of ovarian dysfunction in women with anovulation. Aim of this study is to show and evaluate VD3 level in women who are suffering from polycystic ovarian syndrome.

Methods: This study was conducted on 200 women; group A: (study group) 100 infertile women who were suffering from PCOS and group B: (control group) 100 patients were selected with other cause of infertility than PCOS. US examination, hormonal profile (FSH, LH, AMH, TSH and prolactin level) and laboratory assay of serum VD3 level (postmenstrual) were done for every patient to evaluate relationship between VD3 deficiency and PCOS patients.

Results: There was a significant relationship between group A compared to group B as regards irregular menstrual cycle, clinical hyperandrogenism, LH/FSH ratio and AMH. There was no significant difference between both groups as regards TSH, prolactin and VD3 level. VD was deficient in both groups as it was lower than normal level. There was a negative significant correlation between VD3 level and both hyperandrogenism and AMH.

Conclusions: There was VD3 deficiency in PCO patients and infertile cases due to another factor, and negative significant correlation between VD3 level and clinical hyperandrogenism, LH/FSH ratio, menstrual cycle and AMH.


Keywords


VD3, PCOS, Infertility

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References


Perez-Lopez FR. Vitamin D: the secosteroid hormone and human reproduction. Gynecol Endocrinol. 2007;23:13-24.

Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;77:343-50.

Rainer D, Davis E, Peck J, Hansen K, Craig L. Vitamin D Deficiency and Time to Pregnancy in Women With Polycystic Ovary Syndrome. Fertil Steril. 2012;97:22-4.

Krul-Poel YH, Snackey C, Louwers Y, Lips P, Lambalk CB, Laven JS et al. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. Eur J Endocrinol. 2013;169:853-65.

Knox S, Harris J, Calton L, Wallace AM. A simple automated solid-phase extraction procedure for measurement of 25-hydroxy VD3 and D2 by liquid chromatography-tandem mass spectrometry. Ann Clin Biochem. 2009;46:226-30.

Rahsepar M, Mahjoub S, Esmaelzadeh S, Kanafchian M, Ghasemi M. Evaluation of vitamin D status and its correlation with oxidative stress markers in women with polycystic ovary syndrome. Int J Reprod Biomed. 2017;15:345-50.

Davis EM, Peck JD, Hansen KR, Neas BR, Craig LB. Associations between vitamin D levels and polycystic ovary syndrome phenotypes. Minerva Endocrinol. 2019;44:176-84.

Wehr E, Trummer O, Giuliani A, Gruber HJ, Pieber TR, Obermayer-Pietsch B. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol. 2011;164:741-9.

Eftekhar M, Mirhashemi ES, Molaei B, Pourmasumi S. Is there any association between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes? Arch Endocrinol Metab. 2020;64:11-6.

Li HW, Brereton RE, Anderson RA, Wallace AM, Ho CK. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism. 2011;60:1475-81.

Mahmoudi T, Gourabi H, Ashrafi M, Yazdi RS, Ezabadi Z. Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome. Fertil Steril. 2010;93:1208-14.

Bhide P, Homburg R. Anti-Müllerian hormone and polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2016;37:38-45.

Hashemi AH, Mozdarani H, Naghavi A. Comparison of the Levels of LH and FSH, TSH, Prolactin, Progesterone and Estradiol Hormones between Iranian Infertile Women with Polycystic Ovary Syndrome and Healthy Women. Int J Med Sci Public Health. 2016;5:370-5.

Benetti-Pinto CL, Berini Piccolo VR, Garmes HM, Teatin Juliato CR. Subclinical hypothyroidism in young women with polycystic ovary syndrome: an analysis of clinical, hormonal, and metabolic parameters. Fertil Steril. 2013;99:588-92.

Tagliaferri V, Romualdi D, Guido M, Mancini A, De Cicco S, Di Florio C et al. The link between metabolic features and TSH levels in polycystic ovary syndrome is modulated by the body weight: an euglycaemic-hyperinsulinaemic clamp study. Eur J Endocrinol. 2016;175:433-41.

Kachoie A, Jahanipoor A, Ghahiri A. Evaluation of Serum Prolactin Levels in Patients with Polycystic Ovary Syndrome. Journal of Isfahan Medical School. 2012;30:1-6.

Rashad NM, Abd El-Fatah AH, Lashin ME-B, Abomandour HG, Allam RM. Impact of vitamin D supplementation on cardio-metabolic status and androgen profile in women with polycystic ovary syndrome: placebo-controlled clinical trial. Middle East Fertil Soc J. 2019;24:5.

Arslan E, Gorkem U, Togrul C. Is There a Relationship Between Vitamin D Deficiency Status and PCOS in Infertile Women? Geburtshilfe Frauenheilkd. 2019;79:723-30.

Kozakowski J, Kapuścińska R, Zgliczyński W. Associations of vitamin D concentration with metabolic and hormonal indices in women with polycystic ovary syndrome presenting abdominal and gynoidal type of obesity. Ginekol Pol. 2014;85:765-70.