Correlation between colposcopic impression using Reid’s colposcopic Index and histopathological grading of premalignant lesions of cervix
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20222458Keywords:
Colposcopy, Histopathology, Reid colposcopic indexAbstract
Background: Cancer cervix is in the top rank of gynecological cancers in the developing countries cervical cancer has a long latent period and can be prevented by simple treatment of cervical intraepithelial neoplasm. The incidence of invasive cancer can be decreased by early detection of preinvasive stage which can be treated at the same sitting, “see & treat approach” strategy. Objectives were to estimate the strength of correlation in detecting preinvasive lesions of cervix between colposcopy and directed biopsy and to correlate various socio-demographic data with cervical pre-invasive and invasive lesion. To compare the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of colposcopy with colposcopic directed biopsy.
Methods: On selecting the patients based on the criteria, per speculum examination was done and in the presence of abnormal cervix, advised for PAP smear. Based on PAP smear scaled according to Bethedsa staging, patients were accordingly advised for colposcopy. Reid’s colposcopic index applied and biopsy was taken over the site with highest score and sent for HPE in a labelled bottle with fixative.
Results: Colposcopy when compared to histopathology had a sensitivity of 100 %, specificity of 48.3%, with PPV of 22.4 % and NPV of 100 %. The p value was 0.001 suggesting a significant strength of agreement between colposcopic diagnosis using Reid’s index and histopathological diagnosis.
Conclusions: Correlation of colposcopic impression with directed biopsy is described as the reference investigation or ‘gold standard’ for the diagnosis of cervical precancerous lesions.
Metrics
References
Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108.
Wabinga HR, Parkin DM, Wabwire-Mangen F, Nambooze S. Trends in cancer incidence in Kyadondo County, Uganda, 1960-1997. Br J Cancer. 2000;82(9):1585-92.
Sankaranarayanan R, Shyamalakumary B, Wesley R, Sreedevi Amma N, Parkin DM, Nair MK. Visual inspection with acetic acid in the early detection of cervical cancer and precursors. Int J cancer. 1999;80(1):161-3.
Brotzman GL, Spitzer M, eds. Colposcopy: principles and practice an integrated textbook and atlas, 1st edn. WB Saunders: Philadepphia; 2002:213-224.
Singer A, Monaghan JM, Quek SC DA. Lower genital precancer: colposcopy, pathology and treatment. 2nd edn. Blackwell Science; 2000.
Durdi GS, Sherigar BY, Dalal AM, Desai BR, Malur PR. Correlation of colposcopy using Reid colposcopic index with histopathology- a prospective study. J Turkish Ger Gynecol Assoc. 2009;10(4):205-7.
Nikumbh DB. Cervicovaginal cytology: clinicopathological and social aspect of cervical cancer screening in rural (Maharashtra) India. Int J Heal Sci Res. 2011;1(2).
Bharani Bharti B, Satish PR. role of colposcopy in evaluation of lower female genital tract of 175, symptomatic women. J Obstet Gynecol India. 2004;54(4):372-5.
Verma I, Pundhir P, Kaur T, Jain V, Sood D. Evaluation of Reid’s Combined Colposcopic Index as a predictor of cervical intraepithelial lesion. Int J Reprod Contracept Obstet Gynecol. 2018;7(9):3725.
Mhaske M, Jawadekar SJ, Saundale SG. Study of association of some risk factors and cervical dysplasia/cancer among rural women. Nat J Community Med. 2011;2(02):209-12.
El-Moselhy EA, Borg HM, Atlam SA. Cervical cancer: sociodemographic and clinical risk factors among adult Egyptian females. Adv Oncol Res Treat. 2016;1(1):106.
Raychaudhuri S, Mandal S. Socio-demographic and behavioural risk factors for cervical cancer and knowledge, attitude and practice in rural and urban areas of North Bengal, India. Asian Pac J Cancer Prev. 2012;13(4):1093–6.
Srivastava S, Shahi UP, Dibya A, Gupta S, Roy JK. Distribution of HPV genotypes and involvement of risk factors in cervical lesions and invasive cervical cancer: a study in an Indian population. Int J Mol Cell Med. 2014;3(2):61-73.
Gupta K, Malik NP, Sharma VK, Verma N, Gupta A. Prevalence of cervical dysplasia in western Uttar Pradesh. J Cytol. 2013;30(4):257-62.
Mhaske M, Jawadekar SJ, Saundale SG. Study of association of some risk factors and cervical dysplasia/cancer among rural women. Nat J Community Med. 2011;2(02):209-12.
Taherian AA, Fatahi E SB. Study of risk factors for cervical cancer. A case control study in Isfahan-Iran. Kuwait Med J. 2002;24(2):128-32.
Schiff M, Miller J, Masuk M, van Asselt King L, Altobelli KK, Wheeler CM, et al. Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women. Int J Epidemiol. 2000;29(6):983-90.
Ramadevi E, Mamata N, Madhavi GB, Sudha Rani V, Padmalatha R, Shamili G. A study of correlation between cytology and histopathology with colposcopic findings. Int J Intg Med Sci. 2017;4(4):477-83.
Tatiyachonwiphut M, Jaishuen A, Sangkarat S, Laiwejpithaya S, Wongtiraporn W, Inthasorn P, et al. Agreement between colposcopic diagnosis and cervical pathology: Siriraj hospital experience. Asian Pac J Cancer Prev. 2014;15(1):423-6.