Relation between maternal body mass index and laboratory outcome in normal responder young patients undergoing intracytoplasmic sperm injection cycles
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20222356Keywords:
Fertility, Obesity, Normal responder, BMIAbstract
Background: A lot of studies conducted evaluating the effect of maternal weight on the In Vito Fertilization (IVF) cycles outcome, the results of these studies were conflicting.
Methods: We conducted retrospective cohort study on young normal responding patients attending the clinic for fertility treatment. Patients divided in to three group according to their body mass index (BMI). All patients had intra cytoplasmic sperm injection cycle with antagonist protocol. The IVF laboratory outcome was calculated and compared between the three groups.
Results: The intracytoplasmic sperm injection cycles laboratory outcome was evaluated in the three groups of patients. No significant difference was found between the laboratory out come in the three group.
Conclusions: We concluded that in absence of sever major factor for infertility, maternal BMI has no effect on the laboratory outcome of intra cytoplasmic sperm injection cycles.
References
World Health Organization. BMI Classification. Available at: http://apps.who.int/bmi/index.jsp? introPage=intro_3.html. Accessed on 22 February 2016.
Hartz AJ, Barboriak PN, Wong A, Katayama KP, Rimm AA. The association of obesity with infertility and related menstrual abnormalities in women. Int J Obesity. 1979;3:57-73.
Talmor A, Dunphy B. Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol. 2015;29:498-506.
Weiss JL, Malone FD, Emig D, Ball RH, Nyberg DA, Comstock CH et al. Obesity, obstetric complications, and cesarean delivery rate-a population-based screening study. Am J Obstet Gynecol. 2004;190:1091-7.
Brewer CJ, Balen AH. The adverse effect of obesity on conception and implantation. Reproduction J. 2010;140(3):347-64.
Valckx SD, de Pauw I, de Neubourg D, Inion I, Berth M, Fransen E et al. BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality. Hum Reprod. 2012;27:3531-9.
Rajasingam D, Seed PT, Briley AL, Shennan AH, Poston L. A prospective study of pregnancy outcome and biomarkers of oxidative stress in nulliparous obese women. Am J Obstet Gynecol. 2009;200:395.
Turner N, Robker RL. Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role? Mol Hum Reprod. 2015;21(1):23-30.
Al-Mulhim AS, Al-Hussaini HA, Al-Jalal BA, Al-Moagal RO, Al-Najjar S. Obesity Disease and Surgery. Int J Chronic Dis. 2014;652341.
Luke B, Brown MB, Stern JE, Missmer SA, Fujimoto VY, Leach R. Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Hum Reprod. 2011;26:245-52.
Bellver J, Mifsud A, Grau N, Privitera L, Meseguer M. Similar morphokinetic patterns in embryos derived from obese and normoweight infertile women: a time-lapse study. Hum Reprod. 2013;28(3):794-800.
Bellver J, Pellicer A, García-Velasco JA, Ballesteros A, Remohí J, Meseguer M. Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors. Fertil Steril. 2013;100(4):1050-8.
Wang JX, Davies MJ, Norman RJ. Obesity increases the risk of spontaneous abortion during infertility treatment. Obes Res. 2002;10:551-4.
Dechaud H, Anahory T, Reyftmann L, Loup V, Hamamah S, Hedon B. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol. 2006;127:88-9.
Kudesia R, Wu H, Hunter Cohn K, Tan L, Lee JA, Copperman AB, Yurttas BP. The effect of female body mass index on in vitro fertilization cycle outcomes: a multi-center analysis. J Assist Reprod Genet. 2018;35(11):201-23.
Zander-Fox DL, Henshaw R, Hamilton H, Lane M. Does obesity really matter? The impact of BMI on embryo quality and pregnancy outcomes after IVF in women aged ≤ 38 years. Aust N Z J Obstet Gynaecol. 2012;52(3):270-76.
Goldman KN, Hodes-Wertz B, McCulloh DH. Association of body mass index with embryonic aneuploidy. Fert sterility. 2015;103:744-8.
Meseguer M, Herrero J, Tejera A, Hilligsoe KM, Ramsing NB, Remoh J. The use of morphokinetics as a predictor of embryo implantation. Hum Reprod. 2011;26(10):2658-71.
Koning AM, Mutsaerts MA, Kuchenbecker WK, Broekmans FJ, Land JA, Mol BW et al. Complications and outcome of assisted reproduction technologies in overweight and obese women. Hum Reprod. 2012;27:457-67.
Bartolacci A, Buratini J, Moutier C, Guglielmo MC, Novara PV, Brambillasca F et al. Body mass index affects embryo morphokinetics: a time-lapse study. J Assist Reprod Genet. 2019;36(6):1109-16.
Metwally M, Ong KJ, Ledger WL, Li TC. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril. 2008;90:714-26.
Shah DK, Missmer SA, Berry KF, Racowsky C, Ginsburg ES. Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet Gynecol. 2011;118:63-70.
Matalliotakis I, Cakmak H, Sakkas D, Mahutte N, Koumantakis G, Arici A. Impact of body mass index on IVF and ICSI outcome: a retrospective study. Reprod BioMed Online. 2008;16:778-824.
Stovezky YL, Romanski PA, Bortoletto P. Body mass index is not associated with embryo ploidy in patients undergoing in vitro fertilization with preimplantation genetic testing. Fertil Steril. 2021;116(2):388-95.
Sarais V, Pagliardini L, Rebonato G, Papaleo E, Candiani M, Viganò P. A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes, nutrients J. 2016;8(3):109.
Einarsson S, Bergh C, Friberg B, Pinborg A, Klajnbard A, Karlström AO et al. Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial. Human Reproduct. 2017;32(8):1621-30.
