Case report on perioperative management of combined factor V and VIII deficiency in a patient with prolapse uterus

Bhavani Sree K. P.; Usha Rani G.

doi:10.18203/2320-1770.ijrcog20230553

Authors

Bhavani Sree K. P. Department of Obstetrics and Gynaecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
Usha Rani G. Department of Obstetrics and Gynaecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20230553

Keywords:

Factor V and VIII deficiency, Perioperative management, Vaginal hysterectomy

Abstract

Combined factor V and factor VIII deficiency is a rare autosomal recessive disorder with incidence of one in 10,00,000. We reported a case of seventy-one-year-old patient with third degree uterovaginal prolapse, diagnosed as combined factor V and VIII deficiency and the successful perioperative management during vaginal hysterectomy. With our experience in this, we conclude that for the patient's with factor V and VIII deficiency that the correction should be given for at least 2 weeks post operatively.

Metrics

Metrics Loading ...

References

Oeri J, Matter M, Isenschmid H, Hauser F, Koller F. Congenital factor V deficiency (parahemophilia) with true hemophilia in two brothers. Bibl Paediatr. 1954;58:575-88.

SeligSohn U, Zivelin A, Zwang E. Combined factor V and factor VIII deficiency among non-Ashkenazi Jews. N Engl J Med. 1982;307(19):1191-5.

Zhang B, Ginsburg D. Familial multiple coagulation factor deficiencies: new biologic insight from rare genetic bleeding disorders. J Thromb Haemost. 2004;2(9):1564-72.

Do H, Healey JF, Waller EK, Lollar P. Expression of factor VIII by murine liver sinusoidal endothelial cells. J Biol Chem. 1999;274(28):19587-92.

Gardiner JE, Griffin JH. Studies on human protein C inhibitor in normal and factor V & VIII deficient plasma. Thromb Res. 1984;36(3):197-203.

Nicholas WC, Seligson U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, et al. Mutations in ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell. 1998;93(1):61-70.