Symptoms of hyperprolactinemia with normal serum prolactin: is treatment required?

Authors

  • Deepti Verma Department of Obstetrics and Gynecology, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20161715

Keywords:

Hyperprolactinemia, Prolactin, Galactorrhea

Abstract

Galactorrhea with menstrual abnormalities like oligomenorrhea or amenorrhea point towards a provisional diagnosis of increased serum prolactin levels or hyperprolactinemia. However, as the prolactin hormone is heterogeneous with two forms- the bioactive and the immunoactive forms, patients can have all the features of hyperprolactinemia with normal serum prolactin levels.

References

Kemmann E. Incidence of galactorrhoea. JAMA. 1976;236:2747.

Avner H, Mathew PC. Endocrine Disorders in Novak’s Gynecology. In: Jonathan BS, editor. 13th ed. Philadelphia: Lippincott Williams and Wilkins; 2002. pp. 899

Agarwal M, Das A, Singh SA. Hyperprolactinemia with normal serum prolactin: Its clinical significance. J Hum Reprod Sci. 2010;3(2):111-2.

Leite V, Cosby H, Sobrinho LG, Fresnoza A, Santos AM, Friesen HG. Characterization of big, big prolactin in patients with hyperprolactinaemia. Clin Endocrinol (Oxf). 1992;37:365-72.

Tritos NA, Guay AT, Malarkey WB. Asymptomatic big hyperprolactinemia in two men with pituitary adenomas. Eur J Endocrinol. 1998;138:82-5.

Hughes E, Collins J, Vanderkerckhove P. Bromocriptine for unexplained subfertility in women. Cochrane Database Syst Rev. 2000;2:CD000044.

Downloads

Published

2017-01-05

Issue

Section

Case Reports