Fetomaternal outcome of women with thrombocytopenia in labour


  • Palak Thakkar Department of Obstetrics and Gynecology, Government Medical College, Surat, Gujarat, India
  • Dhwani Desai Department of Obstetrics and Gynecology, Government Medical College, Surat, Gujarat, India
  • Ragini Verma Department of Obstetrics and Gynecology, Government Medical College, Surat, Gujarat, India




Fetal outcome, Maternal outcome, Thrombocytopenia


Background: This study was conducted to study fetomaternal outcome in pregnancy with severity of thrombocytopenia.

Methods: It was a prospective observational study of fetomaternal outcome of women with thrombocytopenia admitted in labour room of a tertiary health care center of south Gujarat for 1-year period (April 2021-March 2022) after official approval from ethical committee. 100 consecutive consenting women with thrombocytopenia admitted in labour room of New Civil Hospital Surat were enrolled in this study.

Results: Mild thrombocytopenia was noted in 68% of the total cases, moderate thrombocytopenia in 27% and severe thrombocytopenia in 5% of cases. 59 subjects belong to age group of 20-25 years, 56 subjects were multipara, 70 subjects were registered antenatally, 68 subjects were delivered beyond 37 weeks of gestation. 48 subjects underwent LSCS and rest were delivered vaginally. 29 subjects had maternal complication. 95 subjects delivered alive baby of which 14 had NICU admission and 5 subjects had preterm still birth baby.

Conclusions: Thrombocytopenia is the second most common haematological finding in pregnancy next to anaemia. Majority of cases generally present at gestational age beyond thirty-seven weeks and belong to category of mild thrombocytopenia. Efforts should be made on improving antenatal registration, screening of maternal thrombocytopenia, early diagnosis and treatment.


Valera MC, Parant O, Vayssiere C, Arnal JF, Payrastre B. Physiologic and pathologic changes of platelets in pregnancy. Platelets. 2010;21(8):587-95.

Matthews JH, Benjamin S, Gill DS, Smith NA. Pregnancy-associated thrombocytopenia: definition, incidence and natural history. Acta Haematol. 1990;84(1):24-9.

Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost. 2003;29(2):125-30.

Hui C, Lili M, Libin C, Rui Z, Fang G, Ling G, et al. Changes in coagulation and hemodynamics during pregnancy: a prospective longitudinal study of 58 cases. Arch Gynecol Obstet. 2012;285(5):1231-6.

Chignard M, Le Couedic JP, Tence M, Vargaftig BB, Benveniste J. The role of platelet-activating factor in platelet aggregation. Nature. 1979;279(5716):799-800.

Fitzgerald DJ, Mayo G, Catella F, Entman SS, FitzGerald GA. Increased thromboxane biosynthesis in normal pregnancy is mainly derived from platelets. Am J Obstet Gynecol. 1987;157(2):325-30.

Nugent D, McMillan R, Nichol JL, Slichter SJ. Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and/or decreased platelet production. Br J Haematol. 2009;146(6):585-96.

Fogerty AE. Thrombocytopenia in Pregnancy: Mechanisms and Management. Transfus Med Rev. 2018;32(4):225-9.

Cines DB, Levine LD. Thrombocytopenia in pregnancy. Blood. 2017;130(21):2271-7.

Menell JS, Bussel JB. Antenatal management of the thrombocytopenias. Clin Perinatol. 1994;21(3):591-614.

Elhassade AS, Nasser ABEN, Details A. Thrombocytopenia at different stages of pregnancy. Int J Clin Biomed Res. 2016;2(2):1-3.

Lester EP, Roth DG. Disseminated intravascular coagulation in pregnancy. J Reprod Med. 1977;19(4):223-32.

Myers B. Diagnosis and management of maternal thrombocytopenia in pregnancy. Br J Haematol. 2012;158(1):3-15.

Asrie F, Enawgaw B, Getaneh Z. Prevalence of thrombo-cytopenia among pregnant women attending antenatal care service at Gondar University Teaching Hospital in 2014, Northwest Ethiopia. J Blood Med. 2017;8:61-6.

Patil AM, Prasade SU, Kathaley MH, Patil P. A study of maternal and fetal outcome of thrombocytopenia in pregnancy. MVP J Med Sci. 2021:16-22.

Sumathy V, Devi C, Padmanaban S. Prospective study of thrombocytopenia in pregnancy. Int J Clin Obstet Gynaecol. 2019;3(1):17-21.






Original Research Articles