Correlation between prolactin, thyroid, LH, FSH, estradiol and progesterone in the infertile women

Siddharth Sharma; Kusum Lata Meena; Aditi Tabiyad; Manish Kumar Bhardwaj; Aditi Jaiswal; Mili Mehta

doi:10.18203/2320-1770.ijrcog20230805

Authors

Siddharth Sharma Department of Obstetrics and Gynecology, SMS Medical College and Hospitals, Jaipur, Rajasthan, India
Kusum Lata Meena Department of Obstetrics and Gynecology, SMS Medical College and Hospitals, Jaipur, Rajasthan, India
Aditi Tabiyad Department of Obstetrics and Gynecology, SMS Medical College and Hospitals, Jaipur, Rajasthan, India
Manish Kumar Bhardwaj Department of Obstetrics and Gynecology, ESIC Medical College and Hospital, Alwar, Rajasthan, India
Aditi Jaiswal Department of Obstetrics and Gynecology, SMS Medical College and Hospitals, Jaipur, Rajasthan, India
Mili Mehta Department of Obstetrics and Gynecology, SMS Medical College and Hospitals, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20230805

Keywords:

Estradiol, FSH, LH, Progesterone, Prolactin, Thyroid, Women infertility

Abstract

Background: An important global health issue, infertility affects a couple’s social, psychological, economic, and sexual well-being. A variety of issues stemming from abnormal hypothalamus pituitary ovarian axis dysfunction make up the hormonal diseases of the female reproductive system. The aim of the study was to find correlation between prolactin, thyroid, LH, FSH, estradiol and progesterone in the infertile women.

Methods: Present study was hospital based descriptive, cross-sectional study. 150 infertile women were required in sample size. Serum LH, FSH, estradiol was measured on day 2 of menstrual cycle and also serum TSH and serum progesterone on day 21.

Results: Around one third (38%) of the cases was married since more than 10 years. Majority 108 (72%) had primary infertility and 50% of the women had history of irregular menstrual cycles. There was significant positive correlation between TSH and prolactin (p value <0.05) and significant negative correlation of TSH with FSH and LH (p value <0.05) and there was insignificant negative correlation of TSH with estrogen (D2) and progesterone (D21). The mean value of TSH in our study was 7.47±1.82 μIU/ml.

Conclusions: TSH has strong positive co-relation between prolactin, FSH and LH indicating role in female infertility. These hormonal evaluations allow a routine etiological approach to the diagnosis of infertility.

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References

Smith JF, Walsh TJ, Shindel AW, Turek PJ, Wing H, Pasch L, et al. Sexual, marital, and social impact of a man’s perceived infertility diagnosis. J Sex Med. 2009;6(9):2505-15.

Williams C, Giannopoulos T, Sherriff EA. Investigation of infertility with the emphasis on laboratory testing and with reference to radiological imaging. J Clin Pathol. 2003;56:261-7.

Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrinol. 2007;66(3):309-21.

Mishra R, Baveja R, Gupta V. Prolactin level in infertility with menstrual irregularities. J Obstet Gynecol India. 2002;52:40-3.

Wright KL. Defining infertility: what infertility means for clinicians and clients. Network. 2003;23(2):4-6.

Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrinol. 2007;66(3):309-21.

Rijal B, Shrestha R, Jha B. Association of thyroid dysfunction among infertile women visiting infertility center of Om Hospital, Kathmandu, Nepal. Nepal Med Coll J. 2011;13(4): 247-9.

Kumkum A, Jasmine K, Shweta G, Pal Ajeshwar N. Hyperprolactinema and its coorelation with hypothyroidism in infertile women. J Obstet Gynecol India. 2006;56(1):68-71.

Kokay IC, Petersen SL, Grattan DR. Identification of prolactin-sensitive GABA and kisspeptin neurons in regions of the rat hypothalamus involved in the control of fertility. Endocrinology. 2011;152(2):526-35.

Cramer DW, Sluss PM, Powers RD, McShane P, Ginsburgs ES, Hornstein MD, et al. Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function? J Assist Reprod Genet. 2003;20(6):210-5.

Saxena S, Gupta R, Agarwal L, Srivastava PC, Mallick AK. Correlation of serum thyroid stimulating hormone and prolactin in female infertility- a case control study. Indian J Obstet Gynecol Res 2016;3(4):388-92.

Turankar S, Sonone K, Turankar A. Hyperprolactinaemia and its comparison with hypothyroidism in primary infertile women. J Clin Diagn Res. 2013;7(5):794-6.

Binita G, Suprava P, Mainak C, Koner BC, Alpana S. Correlation of prolactin and thyroid hormone concentration with menstrual patterns in infertile women. J Reprod Infertil. 2009;10:207‑12.

Sharma LK, Sharma N, Gadpayle AK, Dutta D. Prevalence and predictors of hyperprolactinemia in subclinical hypothyroidism. Eur J Intern Med. 2016;35:106‑10.

Koyyada A, Orsu P. Role of hypothyroidism and associated pathways in pregnancy and infertility: Clinical insights. Tzu Chi J. 2020;32:312-7.

Kalsum A, Jalali S. Role of hyperprolactinemia in fertility. Pak J Med Res. 2002;41;3-15.

Yamaguchi M, Aono T, Koike K, Nishikawa Y, Ikegami H, Miyake A, et al. Effect of nocturnal hyperprolactinemia on ovarian luteal function and galactorrhea. Eur J Obstet Gynecol Reprod Biol. 1991;39:187-91.

Fupare S, Gadhiya BM, Jambhulkar RK, Tale A. Correlation of thyroid hormones with FSH, LH and Prolactin in infertility in the reproductive age group women. Age. 2015;23(2.48):216-22.

Mohan K, Sultana M. Follicle stimulating hormone, luteinizing hormone and prolactin levels in infertile women in north Chennai, Tamil Nadu. J Biosci Res. 2010;1(4):279-84.

Mc Neilly AS. Prolactin and the control of gonadotrophin secretion. J Endocrinol. 1987;115:1-5.