Giant placental chorioangioma presenting as severe polyhydramnios: a case report


  • Prabha Agrawal Department of Obstetrics and Gynaecology, Care Hospital, Hyderabad, Telangana, India
  • Rahul Agrawal Department of Internal Medicine, Care Hospital, Hyderabad, Telangana, India
  • Shabnam S. Fareed Department of Obstetrics and Gynaecology, Care Hospital, Hyderabad, Telangana, India
  • Kinnera R. Ancha Department of Anaesthesiology, Care Hospital, Hyderabad, Telangana, India



Chorioangioma, Polyhydramnios, Pregnancy


Chorioangiomas are the most common non-trophoblastic, benign, vascular tumour of the hemochorial placenta. Small chorioangiomas are usually symptomless, and of no clinical significance while giant ones more than 4 cm in diameter may be complicated by polyhydramnios, foetal cardiomegaly, hydrops fetalis, and foetal growth restriction. We present a case of a 32-year-old primigravida referred to us at 30 weeks of gestation with large placental chorioangioma causing polyhydramnios which was treated by amnioreduction twice over 1 month. On referral the tumour size was about 56 mm size with severe polyhydramnios with amniotic fluid index of 57 cm, with breathlessness and pain abdomen. After relevant investigations and informed consent, she was taken up for caesarean section. 2 litres of clear liquor drained. She delivered a live female baby weighing 1.2 kg with Apgar score of 7 and 8. Patient stood the operation well. Gross and microscopic examination of the placenta confirmed the diagnosis of chorioangioma. Chorioangioma should be considered as differential diagnosis in cases of hydrops fetalis or polyhydramnios. Doppler ultrasound is the method of choice to detect chorioangioma and its vascularity. Giant chorioangiomas complicating pregnancy can be managed conservatively with close surveillance, foetal monitoring and timely intervention to prevent maternal and foetal morbidity and mortality.



Ropacka-Lesiak M, Gruca-Stryjak K, Breborowicz G. Nontrophoblastic placental tumors. Neuro Endocrinol Lett. 2012;33(4):375-9.

Weerakkody Y, Yap J. Placental chorioangioma. Radiopaedia. Available at: articles/placental-chorioangioma. Accessed on 11 November 2022.

Guschmann M, Henrich W, Dudenhausen JW. Chorioangiomas--new insights into a well-known problem. II. An immuno-histochemical investigation of 136 cases. J Perinat Med. 2003;31(2):170-5.

Willis C, Ferguson S, Soydemir F. Placental chorioangioma associated with polyhydramnios and hydrops fetalis. BMJ Case Rep. 2019;12(1):e227828.

Zanardini C, Papageorghiou A, Bhide A, Thilaganathan B. Giant placental chorioangioma: natural history and pregnancy outcome. Ultrasound Obstet Gynecol. 2010;35(3):332-6.

Abdalla N, Bachanek M, Trojanowski S, Cendrowski K, Sawicki W. Placental tumor (chorioangioma) as a cause of polyhydramnios: a case report. Int J Womens Health. 2014;6:955-9.

Vaidyanathan G, Bai A, Perchani J, Said HE, Lakhtakia R. Placental chorioangioma: usual presentation and alternate treatment options. J Case Rep. 2017;30-2.

Hwang DS, Mahdy H. Polyhydramnios. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2022.

Panat V. Chorioangioma: A Case Report. J. Fetal Med. 2020;7:325-9.

Babic I, Tulbah M, Kurdi W. Antenatal embolization of a large placental chorioangioma: a case report. J Med Case Rep. 2012;6:183.






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