A rare case scenario of didelphic uterus with ovarian serous cystadenocarcinoma: an unusual clinical finding


  • Medhavi Sharma Department of Gynaecology, All India Institute of Medical Sciences, Rajkot, Gujarat, India
  • Gaurav Sharma Department of Physiology, All India Institute of Medical Sciences, Rajkot, Gujarat, India
  • Shivangi Varshney Department of Public Health Dentistry, Shree Bankey Bihari Dental College, Ghaziabad, Uttar Pradesh, India




Cystadenocarcinoma, Mullerian duct, Uterine didelphys, Ovarian lesion


Uterine didelphys in women is uncommon. The improper development of the Mullerian ducts during the intrauterine period leads to congenital abnormalities of the female genital system. Mullerian duct canalization or improper fusion leads to a didelphic uterus. About 60% of ovarian neoplasms are epithelial in origin, and the surface epithelium is typically most affected. This case report describes the management of a patient who had previously undergone two caesarean sections for a rare gynecological case of didelphic uterus with unilateral serous cystadenocarcinoma of the ovary.


Heinonen PK. Uterus didelphys: a report of 26 cases. Eur J Obstet Gynecol Reprod Biol. 1984;17:345-50.

Heinonen PK. Clinical implications of the didelphic uterus: long-term follow-up of 49 cases. Eur J Obstet Gynecol Reprod Biol. 2000;91:183-90.

Raga F, Bauset C, Remohi J, Bonilla MF, Simón C, Pellicer A. Reproductive impact of congenital Müllerian anomalies. Hum Reprod. 1997;12:2277-81.

Grimbizis GF, Camus M, Tarlatzis BC, Bontis JN, Devroey P. Clinical implications of uterine malformations and hysteroscopic treatment results. Hum Reprod Update. 2001;7:161-74.

Hutson JM, Grover SR. Malformation syndromes associated with disorders of sex devdopment. Nat Rev Endocrinol. 2014;10:476.

Sharara FI. Complete uterine septum with cervical duplication, longitudinal vaginal septum and duplication of a renal Collecting system. A case report. J Reprod Med. 1998;43:1055.

Kimberley N, Hutson JM, Southwdl BR. Vaginal agenesis, the hymen, and associated anomalies. J Pediatr Adolesc Gynecol. 2012;25:54-8.

Ludwin A, Tudorache S, Martins WP. ASRM Mullerian anomalies classification 2021: a critical review. Ultra Obstet Gynaecol. 2022;59:1-8.

Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J. Cancer Incidence in Five Continents. Int Agency Res Can. 1997;18:50-9.

Pisani P. Burden of cancer in developing countries. Int Agency Res Can. 1994;15:31-9.

Sung H, Ferlay J, Siegel RL. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209-9.

Berek JS, Friedlander M, Hacker NF. Epithelial ovarian, fallopian tube and peritoneal cancer. Gynecol Oncol. 2020;7:15-32.

Scully RE, Young RH, Clements PB. Tumors of the ovary, maldevel-oped gonads, fallopian tube, and broad ligaments. Atlas Tumor Pathol. 1998;3:45-51.

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7-30.

Negri E, Franceschi S, Tzonou A. Pooled analysis of 3 European case-control studies of epithelial ovarian cancer: I. Reproductive factors and risk of epithelial ovarian cancer. Int J Cancer. 1991;49:50-6.

Dhillon PK, Yeole BB, Dikshit R, Kurkure AP, Bray F. Trends in breast, ovarian and cervical cancer incidence in Mumbai,India over a 30-year period, 1976-2005: an age-period-cohort analysis. Br J Cancer. 2011;10:723-30.

Goff BA, Mandel L, Muntz HG, Melancon CH. Ovarian carcinoma diagnosis: results of a national ovarian cancer survey. Cancer Surv. 2000;89:2068-75.

Fealy J, Nelson JH. Adenocarcinoma in one-half of a uterine didelphys. Med Annals District Columbia. 1957;26:76-7.

Fanfanio F, Fagotti A, Restaino G. Endometrial cancer arising in the right cavity diagnosed by 2-dimensional sonography and magnetic resonance imaging. Gynecol Oncol. 2006;101:537-9.






Case Reports