Fetomaternal outcome in pregnancy with fibroid: a prospective observational study
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20231211Keywords:
Fibroid, Perinatal outcome, PregnancyAbstract
Background: Uterine leiomyomas simply called as myomas, fibroids, fibroma, are benign neoplasm derived from smooth muscle cell rests of vessel wall or uterine musculature. Fibroids are rarely observed before puberty, most prevalent during reproductive age group and regress after menopause. They are oestrogen-dependent tumours, and there is evidence that leiomyomas overexpress certain estrogen and progesterone receptors when compared to normal surrounding myometrium.
Methods: The present study was a prospective observational study conducted in Government Lalla Ded Hospital GMC Srinagar over a period of 18 months from May 2021 to November 2022.
Results: Out of 100 patients, only 66 were delivered in our hospital while this study was being conducted. 38% patients had LSCS, 23% had normal vaginal delivery and 5% patients had vaginal delivery followed by curette. Pain was the most common antenatal complication found in 28% of patients, followed by 12% patients with malpresentation, 11% had abortion, 7% had APH and 5% patients had IUD. There was no preterm delivery or PPROM in our study.
Conclusions: The present study demonstrated that the incidence of fibroids was highest in between age group of 25-34 years. The commonest type of fibroid was intramural anterior wall upper segment, followed by intramural posterior wall upper segment. Guarded pregnancy outcome was seen in multiple large fibroids in pregnancy. Cesarean section rate was on higher side especially in multiple fibroids and occupying the lower segment. Decision for cesarean myomectomy should be reserved for selected cases only where the fibroid comes in the incision site or large pedunculated fibroid. Routine cesarean myomectomy should be discouraged. To improve the neonatal outcome in pregnancies with multiple fibroids, cesarean should be done by the staff trained in delivering babies in difficult scenarios.
References
Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188(1):100-7.
Somigliana E, Vercellini P, Daguati R. Fibroids and female reproduction: a critical analysis of the evidence. Hum Reprod Update. 2007;13(5):465-76,
Laganà AS, Vergara D, Favilli A. Epigenetic and genetic land- scape of uterine leiomyomas: a current view over a common gyneco- logical disease. Arch Gynecol Obstet. 2017;296(5):855-67.
Ogedengbe OK. Uterine fibroids. In: Okonofua F, Odunsi K, eds. Contemporary Obstetrics and Gynaecology for Developing Countries. Women’s Health and Action Research Centre (WHARC), Benin City; 2003:202-213.
Manyonda I, Narang L. Current approaches to the management of fibroids. In: Shah D, edr. Clinical Progress in Obstetrics and Gynecology. Jaypee Brother’s Medical Publishers (P) Ltd, New Delhi; 2013:1-21.
Shikora SA, Niloff JM, Bisrian BR, Forse RA, Blackbun GL. Relationship between obesity and uterine leioyomata. Nutrition. 1991;7(4):251-5.
Luoto R, Rutanen EM, Auvinen A. Fibroids and hypertension. A cross-sectional study of women undergoing hysterectomy. J Reprod Med. 2001;46(4):359-64.
Cook JD, Walker CL. Treatment strategies for uterine leiomyoma: the role of hormonal modulation. Semin Reprod Med. 2004:22(2):105-11.
Peddada SD, Laughlin SK, Miner K, Guyon JP, Haneke K, Vahdat HL, et al. Growth of uterine leiomyomata among premenopausal black and white women. Proc Nat Acad Sci USA. 2008;105:19887-92.
Chiaffarino F, Parazzini F, La Vecchia C. Diet and uterine myomas. Obstet Gynecol. 1999:94(3):395-8.
Barbieri RL, Mcshane PM, Ryan KJ. Constituents of cigarrette smoke inhibit human granulosa cell aromatase. Fertil Steril. 1986:46(2):232-6.
Michnovicz JJ, Hershcopf RJ, Naganuma H, Bradlow HL, Fishman J. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med. 1986;315(21):1305-9.
Daniel M, Martin AD, Drinkwater DT. Cigarette smoking, steroid hormones and bone mineral density in young women. Calcif Tissue Int. 1992;50(4):300-5.
Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. Association of physical activity with development of uterine leiomyoma. Am J Epidemiol. 2007;165(2):157-63.
Ratner H. Risk factors for uterine fibroids: reduced risk associated J with oral contraceptives. Br Med J. 1986:293(65533):1027.
Palomba S, Sena T, Morelli M, Noia R, Zullo F, Mastrantonio P. Effect of different doses of progestin on uterine leiomyomas in postmenopausal women. Eur J Obstet Gynecol Reprod Biol. 2002;102(2):199-201.
Parazzini F, Negri E, La Vecchia CA, Fedele L, Rabaiotti M, Luchini L. Oral contraceptive use e and risk of uterine fibroids. Obstet Gynecol. 1992;79(3):430-3.
Qidwai II, caughey AB, Jacoby AF. Obstetric outcome in women with sonographically identified uterine leiomyomata. Obstet Gynecol. 2006;107: 376.
Stout MJ, Odibo AO, Graseck AS, Macones GA, Crane JP, Cahill AG. Leiomyomas at routine second trimester examination and adverse obstetric outcome. Obstet Gynecol. 2010;116(5):1056.
Benson CB, Chow JS, Chang‐Lee W, Hill III JA, Doubilet PM. Outcome of pregnancies in women with uterine leiomyomas identified by sonography in the first trimester. J Clin Ultrasound. 2001;29(5):261-4.
Ross RK, Pike MC, Vessey MP, Bull D, Yeates D, Casagrande JT. Risk factors for uterine fibroids: reduced risk associated with oral contraceptives. Br Med J. 1986;293(6543):359-62.
Orsini G, Laricehia L, Fanelli M. Low-dose combination oral con- traceptives use in women with uterine leiomyomas. Minerva Ginecol. 2002;54(3):253-61.
Exacoustòs C, Rosati P. Ultrasound diagnosis of uterine myomas and complications in pregnancy. Obstet Gynecol. 1993;82:97-101.
Burton CA, Grimes DA, March CM. Surgical management of leiomyomata during pregnancy. Obstet Gynecol. 1989;74:707-9.
Lee HJ, Norwitz ER, Shaw J. Contemporary management of fibroids in pregnancy. Rev Obstet Gynecol. 2010;3(1):20-7
Benson CB, Chow JS, Chang‐Lee W, Hill III JA, Doubilet PM. Outcome of pregnancies in women with uterine leiomyomas identified by sonography in the first trimester. J Clin Ultrasound. 2001;29(5):261-4.
Casini ML, Rossi F, Agostin R, Unfer V. Effects of the position of fibroids on fertility. Gynecol Endocrinol. 2006;22:106-9.
Waliach EE, Vu KK. Myomata uteri and infertility. Obstet Gynecol Clin North Am. 1995;22:791-9.
Lev-Toaff AS, Coleman BG, Arger PH, Mintz MC, Arenson RL, Toaff ME. Leiomyomas in pregnancy: sonographic study. Radiology. 1987;164(2):375-80.
Klatsky PC, Tran ND, Caugley AB, Fujimoto VY. Fibroids and reproductive outcomes: A systematic literature review from conception to delivery. Am J Obstet Gynecol. 2008;198:357-66.
Rice JP, Kay HH, Mahony BS. The clinical significance of uterine leiomyomas in pregnancy. Am J Obstet Gynecol. 1989;160:1212-6.
Singh LR, Mahajan K, Singh NB, Singh WP, Athokpam K, Jinaluxmi RK. Fetomaternal outcome in pregnancies complicated by fibroid. Int J Reprod Contracept Obstet Gynecol. 2021;10:3174-9.
Saleh HS, Mowafy HE, Hameid AA, Sherif HE, Mahfouz EM. Does uterine fibroid adversely affect obstetric outcome of pregnancy? BioMed Res Int. 2018;2018
Posh S, Rafiq S, Nisa Quraishi AU, Wani S. Obstetric outcome in pregnancies complicated with fibroids: a prospective observational study. Matrix Sci Med. 2021;5:12-6.
Noor S, Fawwad A, Sultana R, Bashir R, Jalil H, Suleman N. Pregnancy with fibroids and its obstetric complication. J Ayub Med Col Abbottabad. 2009;21(4):37-40.