A study on the association of diabetes and semen quality in and around Chennai, Tamil Nadu, India

Authors

  • Kalaiselvi S. Department of Biotechnology, Mohamed Sathak College of Arts and Science, Chennai, Tamil Nadu, India
  • Syed Ali M. Department of Biotechnology, Mohamed Sathak College of Arts and Science, Chennai, Tamil Nadu, India
  • Anuradha V. Department of Biochemistry, Mohamed Sathak College of Arts and Science, Chennai, Tamil Nadu, India
  • Subhashini A. Department of Plant Biotechnology and Plant Biotechnology, Quaid-E-Millath Government College, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20230786

Keywords:

Male Infertility, Semen, Diabetes mellitus, HbA1c, Cholesterol, Cortisol

Abstract

Background: Globally prevalence of diabetes is gradually increasing in individual at reproductive stage. Uncontrolled blood sugar affects biological systems including reproductive. Thus, this study was aimed to analyze the association of diabetes and male infertility in and around Chennai.

Methods: Fifty-four male participants who visited the fertility clinic was grouped in two based on the sugar value. An anthropometric measurement, clinical, blood, seminal parameters and life style behaviors was analyzed. All study variables was analyzed to examine the association of diabetes and semen quality.

Results: Study results shows that people with diabetes had abnormal semen parameters as compared to non- diabetic study participants. Pearson’s correlation between the semen parameters and blood sugar value of the study participants showed semen parameters: volume (r=-0.28, p<0.05), count (r=-0.22, p<0.05), and motility (r=-0.23, p<0.05), has a significantly week negative correlation with blood sugar level.  Scatter plots also showed semen parameters:  volume (r2=-0.079), count (r2=-0.048), and motility (r2=-0.053), had a significantly week negative linear correlation with blood sugar level.

Conclusions: From the study it was concluded that the uncontrolled blood sugar levels affect the reproductive health of the study participants.

 

References

Zegers-Hochschild F, Adamson G, De Mouzon J, Ishihara O, Mansour R, Nygren K et al. For ICMART and WHO. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology. Fertil Steril. 2009;92:15204.

Wright J, Duchesne C, Sabourin S, Bissonnette F, Benoit J, Girard Y. Psychosocial distress and infertility: men and women respond differently. Fertil Steril. 1991;55(1):100-8.

So R, Shah IH. Infecundity, Infertility, and Childlessness in Developing Countries. ORC Macro. MEASURE DHS+ (Programme) and World Health Organization. Calverton, MD, Geneva, Switzerland: ORC Macro World Health Organization; 2004.

Mehrotra A, Katiyar DK, Agarwal A, Das V, Pant KK. Role of total antioxidant capacity and lipid peroxidation in fertile and infertile men. Biomed Res India. 2013;24:347-52.

Sharma RS, Gaur KK, Pal PC, Manocha M, Tomar D, Khan AA et al. Semen characteristics: Advancement in andrological assessment. Indian J Clin Biochem. 2005;20(1):173-83.

Temidayo SO, Stefan S. Diabetes mellitus and male infertility. Asian Pac J Reprod. 2018;7:614.

Ding G-L, Liu Y, Liu M-E, Pan J-X, Guo M-X, Sheng J-Z et al. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Asian J Androl. 2015;17(6):948-53.

Rama Raju GA, Jaya Prakash G, Murali Krishna K, Madan K, Siva Narayana T, Ravi Krishna CH. Noninsulin-dependent diabetes mellitus: effects on sperm morphological and functional characteristics, nuclear DNA integrity and outcome of assisted reproductive technique: DNA fragmentation. Andrologia. 2012;44(1):490-8.

Tan O, Ha T, Carr BR, Nakonezny P, Doody KM, Doody KJ. Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles. J Assist Reprod Genet. 2014;31(9):1147-53.

Tavares RS, Escada-Rebelo S, Silva AF, Sousa MI, Ramalho-Santos J, Amaral S. Antidiabetic therapies and male reproductive function: where do we stand? J Reprod Fertil. 2018;155(1):R13-37.

Lwanga SK, Lemeshow S. World Health Organization. Sample size determination in health studies: a practical manual. 1991.

Silea C, Research Institute of the University Bucharest, ICUB, Earth, Environmental and Life Sciences Division, Spl. Independentei. 2018;91-9.

Bucharest, Romania, Cucu I-A, Zarnescu O, Stoian AP, Motofei IG et al. Influence of age on sperm parameters in men with suspected infertility. Rom Biotechnol Lett. 2019;24(1):82-90.

Daousi C, Casson IF, Gill GV, MacFarlane IA, Wilding JPH, Pinkney JH. Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors. Postgrad Med J. 2006;82(966):280-4.

Daousi C, Casson IF, Gill GV, MacFarlane IA, Wilding JPH, Pinkney JH. Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors. Postgrad Med J. 2006;82(966):280-4.

Crujeiras AB, Casanueva FF. Obesity and the reproductive system disorders: epigenetics as a potential bridge. Hum Reprod Update. 2015;21(2):249-61.

Oliveira JBA, Petersen CG, Mauri AL, Vagnini LD, Renzi A, Petersen B et al. Association between body mass index and sperm quality and sperm DNA integrity. A large population study. Andrologia. 2018;50(3).

Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertil Steril. 2008;90(6):2222-5.

Fejes I, Koloszár S, Szöllosi J, Závaczki Z, Pál A. Is semen quality affected by male body fat distribution? Andrologia. 2005;37(5):155-9.

Tsimihodimos V, Gonzalez-Villalpando C, Meigs JB, Ferrannini E. Hypertension and diabetes mellitus: Coprediction and time trajectories. Hypertension. 2018;71(3):422-8.

Muciaccia B, Pensini S, Culasso F, Padula F, Paoli D, Gandini L et al. Higher clusterin immunolabeling and sperm DNA damage levels in hypertensive men compared with controls. Hum Reprod. 2012;27(8):2267-76.

Attaman JA, Toth TL, Furtado J, Campos H, Hauser R, Chavarro JE. Dietary fat and semen quality among men attending a fertility clinic. Hum Reprod. 2012;27(5):1466-74.

Ortiz R, Kluwe B, Odei JB, Echouffo Tcheugui JB, Sims M, Kalyani RR et al. The association of morning serum cortisol with glucose metabolism and diabetes: The Jackson Heart Study. Psychoneuroendocrinology. 2019;103:25-32.

Pugliese MN, Gonzalez D, Jamardo JJ, Ariagno JI, Repetto H, Jacobsen D. Association of Cortisol and Vitamin D in Seminal Plasma with Sperm Quality. Austin Androl. 2018;3(2).

Jing-Zhen Zhu X-Y, Dong J-J, Liang Z-Q, Zhang X-Y, Hu L-K. Effects of diabetes mellitus on semen quality in adult men: a systematic review and meta-analysis. Int J Clin Exp Med. 2017;10:11290-303.

Agbaje IM, Rogers DA, McVicar CM, McClure N, Atkinson AB, Mallidis C, et al. Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod. 2007;22(7):1871-7.

Ali ST, Rakkah NI. Neurophysiological role of sildenafil citrate (Viagra) on seminal parameters in diabetic males with and without neuropathy. Pak J Pharm Sci. 2007;20(1):36-42.

Delfino M, Imbrogno N, Elia J, Capogreco F, Mazzilli F. Prevalence of diabetes mellitus in male partners of infertile couples. Minerva Urol Nefrol. 2007;59(2):131-5.

Bhattacharya SM, Ghosh M, Nandi N. Diabetes mellitus and abnormalities in semen analysis: Diabetic seminopathy. J Obstet Gynaecol Res. 2014;40(1):167-71.

Abdullah AE, Morsi AN. Elhassan Faragalla MM, Elsayed MM. The association between male infertility and diabetes mellitus. J Pharm Biomed Sci. 2014;04(12):1097-102.

Gaur DS, Talekar M, Pathak VP. Effect of cigarette smoking on semen quality of infertile men. Singapore Med J. 2007;48(2):119-23.

Pasqualotto FF, Sobreiro BP, Hallak J, Pasqualotto EB, Lucon AM. Cigarette smoking is related to a decrease in semen volume in a population of fertile men. BJU Int. 2006;97(2):324-6.

Richthoff J, Elzanaty S, Rylander L, Hagmar L, Giwercman A. Association between tobacco exposure and reproductive parameters in adolescent males. Int J Androl. 2008;31(1):31-9.

Jensen TK, Swan S, Jørgensen N, Toppari J, Redmon B, Punab M et al. Alcohol and male reproductive health; a cross sectional study of 8,344 healthy men from Europe and USA. Hum Reprod. 2014;29:1801-9.

Anderson K, Nisenblat V, Norman R. Lifestyle factors in people seeking infertility treatment - A review. Aust N Z J Obstet Gynaecol. 2010;50(1):8-20.

Gollenberg AL, Liu F, Brazil C, Drobnis EZ, Guzick D, Overstreet JW et al. Semen quality in fertile men in relation to psychosocial stress. Fertil Steril. 2010;93(4):1104-11.

Corona G, Giagulli VA, Maseroli E, Vignozzi L, Aversa A, Zitzmann M et al. Testosterone supplementation and body composition: results from a meta analysis study. Eur J Endocrinol. 2016;174:R99-116.

Spielberger CD, Gorsuch RL, Lushene RE, Jacobs GA. In: STAI: Manual for the State-Trait Anxiety Inventory. Alto P, Ca, editors. Consulting Psychologists Press. 1970.

Ragni G, Caccamo A. Negative effect of stress of in vitro fertilization program on quality of semen. Acta Eur Fertil. 1992;23(1):21-3.

Tolahunase M, Bisht S, Sagar R. Effect of yoga on quality of life and seminal quality in male infertility patients with major depressive disorder (MDD): randomized controlled trial. Andrology. 2016;4.

Wise LA, Cramer DW, Hornstein MD, Ashby RK, Missmer SA. Physical activity and semen quality among men attending an infertility clinic. Fertil Steril. 2011;95(3):1025-30.

Salas-Huetos A, Bulló M, Salas-Salvadó J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update. 2017;23(4):371-89.

Downloads

Published

2023-03-28

Issue

Section

Original Research Articles