Assessment of thyroid dysfunction in women with menstrual disorders in reproductive age group
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20231219Keywords:
Menstrual disorder, Reproductive age, Thyroid dysfunctionAbstract
Background: Thyroid disorders are among the most common endocrine disorders in the world. Thyroid dysfunction can disrupt a variety of metabolic and physiological processes, including the menstrual cycle. The purpose of this study was to discover a pattern of thyroid dysfunction in women with menstrual disorders.
Methods: It is a cross-sectional study that includes 116 women. With reproductive age menstrual disorder. Thyroid dysfunction was tested in women who had menstrual problems. Serum free triiodothyronine (T3), free thyroxine (T4), and thyroid stimulating hormone (TSH) levels were used to assess thyroid function.
Results: The mean age of study patients was 25.7±6.8 years. The most common menstrual disorder was irregular cycle 72.5%, amenorrhea 21.9%, and menorrhagia 5.6%. The majority of the patients were between the ages of 15 and 24 (51.1%), followed by 25-34 (36.1%) and 35-45 (12.9%). The mean free T3 and T4 levels were 2.911.05 pg/ml and 1.420.57 ng/dl, respectively. TSH was 2.0 mIU/L on average (IQR, 1.0-4.0). Thyroid dysfunction was observed in 25.8% of the women (n=60). Subclinical hypothyroidism (14.2%, n=33) was the most common thyroid dysfunction, followed by subclinical hyperthyroidism (6.9%, n=16), overt hyperthyroidism (3%, n=7), and overt hypothyroidism (1.7%, n=4).
Conclusions: The study reveals that women with menstrual disorders frequently have thyroid dysfunction, particularly subclinical hypothyroidism. In order to rule out thyroid disorders as potential etiological agents for menstrual disturbances, it may therefore be advantageous to screen patients with menstrual disorders for thyroid function.
Metrics
References
Gandi SR, Vishwekar P, Yadav RS, Chauhan N. Study of thyroid dysfunction in women with menstrual disorders: A prospective study. MedPulse- Int J Gynaecol. 2019;9(3):89-93.
Poppe K, Glinoer D. Thyroid autoimmunity and hypothyroidism before and during pregnancy. Human Reprod Update. 2003;9:149-61.
Kochupillai N. Clinical endocrinology in India. Curr Sci. 2000;79:1061-7.
Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489-99.
Gowri M, Radhika BH, Harshini V, Ramaiaha R. Role of thyroid function tests in women with abnormal uterine bleeding. Int J Reprod Contracept Obstet Gynecol. 2014;3(1):54-7.
Sangita AN, Sarbhai V, Yadav N, Paul M, Ahmad A, Ajmani AK. Role of thyroid dysfunction in patients with menstrual disorders in tertiary care center of walled city of Delhi. J Obst Gynecol India. 2016;66(2):115-9.
Sharma N, Sharma A. Thyroid profile in menstrual disorders. JK Science. 2012;14(1):14-7.
Abraham R, Murugan VS, Pukazhvanthen P. Thyroid disorders in women of puducherry. Indian J Clin Biochem. 2009;24(1):52-9.
Thomas R, Reid RL. Thyroid disease and reproductive dysfunction: a review. Obstet Gynecol. 1987;70:789-98.
Kakuno Y, Amino N, Kanoh M. Menstrual disturbances in various thyroid disease. Endocr J. 2010;57(12):1017-22.
Sharma N, Sharma A. Thyroid profile in menstrual disorders. JK Science. 2012;14(1):14-7.
Pahwa S, Gupta S, Kaur J. Thyroid dysfunction in dysfunctional uterine bleeding. JARBS. 2013;5(1):78-83.
Karki C, Shrestha N, Rayamajhi R. Gynecological disorders of adolescent girls at Kathmandu medical college teaching hospital. Nepal J Obstet Gynaecol. 2014;3(2):44-7.
Khatiwada S, Kc R, Sah SK, Khan SA, Chaudhari RK, Baral N, et al. Thyroid dysfunction and associated risk factors among nepalese diabetes mellitus patients. Int J Endocrinol. 2015;2015:570198.
Khatiwada S, Kc R, Gautam S, Lamsal M, Baral N. Thyroid dysfunction and dyslipidemia in chronic kidney disease patients. BMC Endocr Disord. 2015;15:65.
Kakuno Y, Amino N, Kanoh M, Kawai M, Fujiwara M, Kimura M, et al. Menstrual disturbances in various thyroid diseases. Endocr J. 2010;57(12):1017-22.
Koutras DA. Disturbances of menstruation in thyroid disease. Ann N Y Acad Sci. 1997;816:280-4.
Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrinol (Oxf). 2007;66(3):309-21.
Downloads
Published
How to Cite
Issue
Section
